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Cytokine Storm: What Happens When Your Immune System Overreacts?

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Cytokine

As we move through 2020 and talk of COVID-19 is everywhere you turn, a healthy immune system is at the forefront of many people’s minds – and for good reason. 

When it comes to fighting off harmful infections like coronavirus, your immune system is the most effective weapon you have. Like a well-trained army, your immune system is designed to quickly spring into action at the “sound” of danger. 

And one of the key players responsible for “sounding the alarm” is interleukin-6 (IL-6). Today we’re going to dive into interleukin-6’s role in immune function –  and more importantly, how to keep your levels in check so your immune system runs at full force.

 

What is Interleukin-6?

IL-6 is a type of protein known as a cytokine. You see, your immune system is designed to protect you against potentially harmful microorganisms. It does this by having an army of immune cells constantly scouring your body for potential threats. When a threat is detected, your cells signal the immune cells to neutralize the foreign invader.

This immune response is dependent on effective communication between your cells. And one of the primary ways that your cells communicate with each other is through the secretion of small proteins known as cytokines. Cytokines are molecular messengers that signal cells to perform a certain action.1 IL-6 is one of the cytokines released when your body detects a foreign microbe or an injury.

Many cells have the ability to produce IL-6, but it’s mainly produced by your white blood cells, also known as leukocytes.2 Because it’s produced primarily by leukocytes, it makes sense that IL-6 plays an integral role in the immune response. 

Let’s take a look at the exact role IL-6 plays in the function of your immune system.

 

Interleukin-6’s Role in Immune Function

When released, IL-6 begins the “inflammatory cascade”, which is the sequential coordinated activation of your immune response. This is a very complex process, but essentially it’s similar to an assembly line – each step triggers another step to happen until there’s an end product.

Interestingly, IL-6 has both pro-inflammatory and anti-inflammatory effects on the body depending on what cells are targeted and how much IL-6 is released. Some of interleukin-6’s effects on the immune system include:

  • Stimulating other signaling proteins in the acute phase of inflammation – providing crucial communication so your body can launch an effective attack against the perceived threat3
  • Aiding the body in resolving acute inflammation and returning to homeostasis. IL-6 helps control inflammation by essentially “capping” levels of other pro-inflammatory cytokines, thus preventing an overreaction of the immune system3
  • Regulating the expression and differentiation of monocytes into macrophages – which are the cells that engulf harmful microorganisms so they can be removed by the body4
  • Promoting B-cells production of antibodies – proteins produced by immune cells that recognize and bind to foreign invaders5

Interleukin-6’s crucial role in your body’s deployment of the immune response is quite complex. Considering that this cytokine has both pro-inflammatory and anti-inflammatory properties, it might leave you wondering – so is interleukin-6 good or bad? 

 

So, is Interleukin-6 Good or Bad?

The answer to that question is – it’s complicated. IL-6 plays a key role in triggering inflammation and stimulating the immune response. And while the term inflammation gets a bad rap, you need inflammation in order to appropriately address and neutralize any potential threats. So in a balanced and healthy immune response, IL-6 is more than good, it’s absolutely crucial.

But problems can arise when IL-6 and other cytokine levels remain high for too long or when levels rise at a rapid pace and overwhelm the body. This causes inflammation to go unchecked and climb to dangerous levels.

This flooding of cytokines and overactivation of the immune system is actually what poses such a threat when it comes to certain infections – particularly in severe cases of COVID-19.

 

Interleukin-6 and COVID-19

While COVID-19’s exact mechanism of injury is still up for debate, research has found that COVID-19 cases that spiral into detrimental and critical levels all have something in common – an excess accumulation of cytokines and immune cells in the lung tissues. This exaggerated immune response and accumulation of cytokines and immune cells is known as a “cytokine storm.”

Severe stages of COVID-19 are characterized by extremely high levels of cytokines, including IL-6.6 This overzealous immune response and build-up of cytokines is in part what causes the acute respiratory distress seen in critical COVID-19 patients. 

So what can you do to keep your cytokine levels balanced and bolster your defenses against coronavirus?

 

Factors That Impact Interleukin-6 and Your Immune System

Currently, there’s no cure for COVID-19 and it’s likely this virus isn’t going away anytime soon. This means that keeping your immune system in tip-top shape is your best bet when it comes to protecting yourself against coronavirus. 

There are many factors that influence the health of your immune system and your IL-6 levels. And fortunately, you have control over most of these factors.

Keeping your IL-6 levels balanced requires an all-encompassing approach of prioritizing the health of your entire immune system. To keep your immune system functioning at its fullest capacity, here’s what I recommend: prioritizing sleep, eating well, and managing stress.

 

Prioritize Sleep

Sleep deprivation has been found to significantly increase pro-inflammatory markers and be a major contributor to chronic inflammation.7 Chronic inflammation is like kryptonite to your immune system. The long term stimulation overworks your immune system, burning it out and decreasing its ability to effectively protect you.

When it comes to sleep, you want to focus on both quantity and quality. Do your best to get a minimum of six hours of sleep each night – although seven to eight is ideal. To ensure your sleep is high-quality and restful sleep, I recommend:

  • Keeping your room cool and dark
  • Shutting off all electronics at least 30 minutes before bedtime
  • Using a fan or white noise to block out any outside sounds that might disturb you

If you have a hard time falling or staying asleep, you can also try a natural sleep aid like Lipocalm – a powerful blend of natural compounds perfectly calibrated to help ease your body into deep restorative sleep.

 

Focus on a Healthy Diet

The food you eat is either pro- or anti-inflammatory. Pro-inflammatory foods cause chronic low-level inflammation that overworks and burns out your immune system. Over time, this can throw your whole system out of whack and dampen your immune system’s ability to appropriately respond to potential threats 

Consistently making the choice to eat a diet that is centered around anti-inflammatory foods is one of the most potent ways you can support your immune system. That doesn’t necessarily mean your diet has to be complicated. I recommend simply focusing on building your meals around wholesome, real foods like fresh veggies and fruits, high-quality meat, and healthy fats.

Manage Your Emotions 

Stress and negative emotions release a cocktail of hormones that can put a major damper on your immune system. In fact, some of the stress hormones can even temporarily shut down your immune system – leaving you vulnerable and throwing your immune system off-kilter. 

While stress and negative emotions are unavoidable, there are some simple ways you can incorporate more positive emotions in your life to balance out the negativity. Things like finding ways to prioritize connection with others, spending a few minutes meditating each day, and making time for fun and relaxation. This may seem unrelated to your ability to fight off infection, but they go a long way in keeping your immune system firing on all cylinders.

  

Incorporate Immune-Supporting Supplements

Supplements are a powerful and effective way to support your immune system. Some of the best supplements for promoting healthy and balanced immune function are:

 

  • Omega Curcumin: A highly bioavailable and optimally absorbed blend of curcuminoid and turmeric extracts help your body modulate cytokine production to maintain a healthy and balanced immune response.

 

  • Buffered C Powder: Vitamin C is a potent antioxidant known for its critical role in proper immune function.
  • Vitamin D3: Vitamin D plays a key role in immune system function and modulation and a deficiency has been directly linked to weakened immune function. 
  • Probiotics: The health of your gut and the health of your immune system are intricately lin
  • ked and many of your immune cells reside in your gut. Regularly introducing beneficial gut flora, ensures your gut and immune system stay balanced.
  • N-Acetyl Cysteine: N-Acetyl Cysteine is a necessary ingredient for your body to make important antioxidants like glutathione that keep your immune system healthy. 

Manage Your Emotions 

Stress and negative emotions release a cocktail of hormones that can put a major damper on your immune system. In fact, some of the stress hormones can even temporarily shut down your immune system – leaving you vulnerable and throwing your immune system off-kilter. 

 

While stress and negative emotions are unavoidable, there are some simple ways you can incorporate more positive emotions in your life to balance out the negativity. Things like finding ways to prioritize connection with others, spending a few minutes meditating each day, and making time for fun and relaxation. This may seem unrelated to your ability to fight off infection, but they go a long way in keeping your immune system firing on all cylinders.  

Staying Safe Amidst COVID-19

Your immune system is a complicated network intricately connected to every other organ and system in your body. Understanding the role of cytokines like IL-6 is important, but in order to truly maximize your immune system, it takes a big picture approach. Prioritizing your overall health and well-being is one of the most effective ways you can bolster your defenses against harmful germs like coronavirus.

And when it comes to your health, I always say that you are your own best advocate. That’s why I’m dedicated to bringing you the resources you need to stay informed and maximize your health. If you’re ready to dive a little deeper and get all of my best recommendations on staying healthy from the inside out, I encourage you to sign up for my newsletter. You’ll get exclusive content and all of my best tips delivered straight to your inbox. Just type in your name and email address below!

Now it’s time to hear from you. Were you surprised to learn about interleukin-6’s role in inflammation? What are you doing to prioritize your immune health? Leave your questions and thoughts in the comments below!

 

References

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785020/
  2. https://www.cancer.gov/publications/dictionaries/cancer-terms/def/interleukin-6
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226076/
  4. https://www.frontiersin.org/articles/10.3389/fmicb.2019.01057/full
  5. https://www.hindawi.com/journals/ijr/2011/721608/
  6. http://orthomolecular.org/resources/omns/v16n11.shtml
  7. https://lipidworld.biomedcentral.com/track/pdf/10.1186/1476-511X-9-125

* These statements have not been evaluated by the Food and Drug Administration. The product mentioned in this article are not intended to diagnose, treat, cure, or prevent any disease.   The information in this article is not intended to replace any recommendations or relationship with your physician.  Please review references sited at end of article for scientific support of any claims made.

Categories: Autoimmune Health, Covid-19By Dr. Jill C. Carnahan, MD, ABIHM, IFMCPMay 9, 202023 Comments
Tags: COVID-19CytokineCytokine stormimmune systeminflammationInterleukin-6Interleukin-6 and COVID-19Interleukin-6’s Role in Immune Function
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Author: Dr. Jill C. Carnahan, MD, ABIHM, IFMCP

https://www.jillcarnahan.com/

Dr. Jill is Your Functional Medicine Expert! She uses functional medicine to help you find answers to the cause of your illness and addresses the biochemical imbalances that may be making you feel ill. She'll help you search for underlying triggers contributing to your illness through cutting edge lab testing and tailor the intervention to your specific needs as an individual. She may use diet, supplements, lifestyle changes or medication to treat your illness but will seek the most gentle way to help your body restore balance along with the least invasive treatment possible. Dr. Jill is a functional medicine expert consultant and treats environmental and mold-related illness as well

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23 Comments

  1. Peggy says:
    May 12, 2020 at 1:35 pm

    Always enjoy your articles!🤗
    I’ve tried many forms of meditation and felt quite unsuccessful but recently started using Brain Tap and find it very relaxing. Along with prayer and Christian music It has been very helpful during this unusual pandemic time.

    Reply
  2. Val Uria says:
    May 13, 2020 at 7:15 am

    Why would you tout an ascorbic acid vitamin C which is synthetic over a whole food C? What I’ve read is the synthetic version can actually do more harm than good over time. Would love more info on this if you can direct me.

    Reply
    • Jill Carnahan, MD says:
      May 15, 2020 at 11:12 pm

      Good quality professional grade vitamin C is still highly beneficial

      Reply
  3. Val Uria says:
    May 13, 2020 at 7:28 am

    Also interested about your take on elderberry and immune function, specifically as it stimulates these particular cells that give rise to cytokines. In a normal immune response this sounds great but how do we know when it gets out of hand? Is an over reactive immune system one like we see in those with allergies and auto immune issues? Would these ppl be more at risk and perhaps do better to avoid elderberry? Or is it never wrong to avoid something that supports the immune system?

    Reply
    • Jill Carnahan, MD says:
      May 15, 2020 at 11:13 pm

      I have seen no evidence that elderberry is harmful

      Reply
    • Carmen says:
      May 17, 2020 at 10:36 am

      Such a great question!
      It is my understanding that Elderberry has a way of disarming the virus’s ability to attach to a cell before the duplicating information in the DNA/RNA process happens (which is the virus’s way of masking itself in the body)

      I’m not exactly sure how or if this relates to the cytokine storm.

      I am not clear if the Elderberry accomplishes this task through boosting the production of a certain leucocyte which produces cytokines such as Interleukin-6 or through another avenue.

      I have a similar question I am going to post here in relation to immune mushrooms.

      Reply
  4. Marla says:
    May 13, 2020 at 7:48 am

    You’re the best! Thank for caring and sharing…

    Reply
  5. Jon says:
    May 13, 2020 at 8:27 am

    Don’t forget that laughing is good for the body also !

    Reply
  6. Pat says:
    May 13, 2020 at 12:14 pm

    I have been a big fan of yours for many years. My question concerns immune compromised people like myself who are dealing with a lot of inflammation in their bodies. I have been battling mold toxicity for the last 10 years. Because of my genes, I can get better but never stay better…..just keep getting reinfected. What can I do to super size my immune system so I am not so vulnerable to this virus. I am Already taking glutathione daily, NAC, argentyn 23, 1000 mg of Vit C, and CuraMed to bring down my inflammation.
    Thank you so much for all the information you provide on your web site. It has been invaluable to me ..

    Reply
  7. Denise LeSage says:
    May 13, 2020 at 12:24 pm

    Hi Jill, thanks for the great information. I have MCAS and take a few H1 meds to help keep my mast cells down and some help with cytokines. Just wondering if those meds (ketotifen, singular, chromolyn sodium, LDN) help at all with the symptoms created when contracting COVID-19? Thanks for all your wonderful articles. I love learning from you. Thanks, Denise

    Reply
    • Jill Carnahan, MD says:
      May 15, 2020 at 11:11 pm

      These meds do down-regulate inflammatory response in the body so it is possible they would help

      Reply
  8. Shelly Armstrong says:
    May 14, 2020 at 12:34 am

    Excellent article. Thank you. Please add me to your mailing list

    Reply
  9. Mike K says:
    May 14, 2020 at 10:21 pm

    Could blocking RANTES from binding to CCR5 expressed on immune cells be the key to quieting the cytokine storm? RANTES seems to be more severely elevated than IL-6 in COVID-19 patients.

    https://www.pharmacytimes.com/news/novel-drug-may-reduce-inflammation-in-critical-covid-19-patients?sp_url=coronavirus

    https://youtu.be/xR5KQuPeFp8

    Thanks for all your informative articles.

    Reply
  10. Carmen says:
    May 17, 2020 at 11:27 am

    I have a question about immune mushrooms (cordyceps, reshi, turkey tail, etc) that are high in polyphenols that increase the production of leukocytes and thus macrophages. I am curious if these mushrooms were taken during a COVID infection or case of COVID, if they would contribute to this cytokine storm, increasing the inflammatory response.

    Thank you so much for all the educational information you provide.

    Reply
  11. Mary Wooten says:
    May 17, 2020 at 11:34 am

    Thank you for the information

    Reply
  12. Sara Christopher says:
    May 17, 2020 at 2:42 pm

    Any extra tips for this with MCAS? I have a 2.5 year old with suspected MCAS, and the inflammatory response Covid 19 seems to activating only some is a bit terrifying. So we are inside and outside around our house for awhile. We have worked with Judy in getting many nutritional supports in place and he is doing well with a still very limited diet. He does take cromolyn and ketotifen as well. Your articles have not surprised me about COVOD 19 with all I have learned about the immune system- far more than I ever wanted to know, however, now I am fascinated.

    I know the NIH put out a small study discussing mast cells playing a role with COVID 19 (which would be no surprise to me at). Just wondering if you have any more thoughts for these mast cell strugglers. One in particular is glutathione. He is not on it, but I’ve always been curious for many reasons having to do with his chemical sensitivities in foods…particularly with salicylates. I’ve also seen it pop up some with Covid 19. I just have no clue if there is a safe dosing for children and we just used our last appointment with Judy. 🙂 Sorry. I could go on for a long time. I really respect what you write always and honestly always want to just sit down and drill you with questions and share my findings. I respect your knowledge about MCAS.

    Reply
    • Jill Carnahan, MD says:
      July 12, 2020 at 5:20 pm

      Hi Sara,
      You may want to read my article on MCAS here for more information on treatments.
      warmly
      Dr Jill

      Reply
  13. Martha says:
    May 30, 2020 at 9:57 am

    Jill,
    I believe you have said in the past that you have the HLA-DR gene that does not recognize Biotoxins. In your experience, do those who have this gene have a high risk of serious effects from Covid-19?

    Reply
    • Jill Carnahan, MD says:
      May 30, 2020 at 11:12 pm

      There are HLA’s associated with different outcomes in illness from COVID-19 but they are different from biotoxin susceptible genes. more here https://jvi.asm.org/content/early/2020/04/16/JVI.00510-20

      Reply
  14. Gaylynn Rediger says:
    June 29, 2020 at 10:14 pm

    Please send me your newsletters.
    Thank you!

    Reply
    • Jill Carnahan, MD says:
      June 30, 2020 at 6:19 am

      Of course. I will add you to our newsletter list.

      Reply
  15. Tony Karalekas says:
    December 12, 2020 at 9:59 pm

    Jill,

    I am a COVID Long Hauler of 9 months. Watching your videos about mold and MCAS, pathogens, HLA.

    Do you think the HLA-DR genes you mention with mold and Lyme (and how some people’s immune system “over reacts” to antigens)…. may be the cause of Long Haulers?

    Many young/fit people seemingly clear the virus, but are left in a severe, debilitating illness + systemic inflammatory state. I’m one of them.

    Is it possible that Long COVID is following the same pattern as Lyme or mold in this sense? Many with autonomic dysfunction, neurological issues, fatigue, MCAS type symptoms.

    Thank you for all your work!

    Reply
    • Jill Carnahan, MD says:
      December 25, 2020 at 10:45 pm

      yes, Tony – this is all inflammatory cytokines gone a bit mad

      Reply

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