Aging is one of life's few certainties – no matter how much we might wish otherwise, it's a journey we all must take. If we’re lucky enough to grow to a ripe old age, we’ll inevitably experience the changes that come with aging. But what exactly does it mean to age? And what causes these inevitable changes?
Today, we’re going to explore the science behind aging, the underlying mechanisms that drive the cardinal signs of old age – and most importantly, we’ll touch on some ways you can combat the effects of these processes so you can age with grace. Let’s dive in.
What Exactly Is Aging?
Aging is a complex, multifaceted process characterized by the gradual decline in physiological function and the increased susceptibility to diseases and death that occurs over time. Imagine your body as a finely tuned machine. When it's new, everything works smoothly, with all parts operating in harmony. But over time, even the best machines experience wear and tear.
Aging is a bit like that – it's the natural, gradual process where our bodies and minds undergo various changes as the years go by. But what exactly is it that causes these processes to gradually deteriorate and inevitably create the hallmark signs of aging?
So, What Causes Us To Age?
Our well-being, our longevity, and how we age is a complex process. While we don’t have all of the answers when it comes to aging, research has identified 12 distinct underlying mechanisms that drive aging. Let’s zoom in on each of these 12 processes:1,2,3,4
Genomic Instability:
Your DNA is like an intricate piece of code, holding all the instructions for your body's functions. Now, picture that code getting a little scrambled over time – maybe a letter gets swapped here, and a sequence gets deleted there. That's genomic instability.
It's like a glitch in the system, where the DNA within your cells starts accumulating damage from things like exposure to environmental factors, toxins, and errors during DNA replication. Over time, accumulated DNA damage can lead to potential errors in how your body operates – impairing cellular function and increasing the risk of age-related diseases.
Telomere Attrition:
Imagine chromosomes (the structures that hold your DNA) as shoelaces, with telomeres acting as the protective plastic caps at the ends. Telomeres are crucial because they prevent the DNA strands from fraying or sticking together – similar to the way those plastic caps keep your shoelaces from unraveling. Now, here's the thing: every time your cells divide to make new ones, those telomeres get a bit shorter in a process called telomere shortening.
With each cell division, telomeres get shorter and shorter until they become too short to protect chromosomes – leading to cellular senescence or cell death. This process contributes to aging by limiting the ability of cells to regenerate and maintain tissue function.
Epigenetic Alterations:
DNA serves as the ultimate instruction manual for your body, right? Well, epigenetics is like the editor-in-chief – deciding which parts of that manual get read and which ones get tucked away on the shelf. Epigenetics essentially turn genes on or off without actually changing the underlying DNA sequence.
As we age, our epigenetic landscape can start to shift – altering which genes are expressed and which are silenced. These epigenetic changes can alter important cellular functions – leading to cellular dysfunction and age-related changes.
Loss of Proteostasis:
Picture your cells as busy little factories, constantly churning out proteins to keep everything running smoothly. Proteostasis is an important process that serves as a sort of quality control – maintaining the delicate balance between making new proteins and getting rid of old or damaged ones. Proteostasis ensures that only the best proteins make the cut and that any misfolded or worn-out ones are promptly recycled.
But as we age, this system can start to falter. This loss of proteostasis means that damaged proteins can start to accumulate within our cells, gumming up the works and interfering with essential cellular functions, leading cellular dysfunction and contributing to the hallmark signs of aging.
Deregulated Nutrient Sensing
Within your cells, there are tiny sensors that can detect when nutrients like glucose, amino acids, and fats are on the menu. These sensors regulate nutrient and energy intake – ensuring that each cell gets just the right amount of fuel to keep things humming along smoothly. This process, known as nutrient sensing, is crucial for regulating metabolism, energy production, and even cell growth and survival.
As we age, these nutrient-sensing systems can start to get a bit out of whack. This deregulated nutrient sensing can lead to all sorts of metabolic mayhem – from insulin resistance to dysregulated lipid metabolism. And when our cells aren't getting the nutrients they need, it can set off a domino effect that contributes to the aging process, increasing the risk of age-related diseases like diabetes, cardiovascular disease, and even neurodegenerative disorders.
Mitochondrial Dysfunction
Mitochondria function as microscopic energy factories – churning out the energy our cells need to fuel everything from blinking to running marathons. Mitochondria even have their own DNA, separate from the DNA in our cell's nucleus, which is kind of like having a backup generator just in case. But, like any well-oiled machine, mitochondria can start to show signs of wear and tear as we age.
This mitochondrial dysfunction can come in many forms – maybe the DNA inside the mitochondria gets damaged, or the mitochondria themselves start to lose their shape and function. And decreased energy production can lead to all sorts of problems that can set the stage for the gradual decline we experience as we age.
Cellular Senescence
As our cells go about their business, they inevitably accumulate all sorts of damage from things like DNA mutations or oxidative stress. When the damage reaches a certain point, your cells call it quits – they stop dividing and enter a state of permanent growth arrest.
While cellular senescence might sound like a peaceful retirement, it can actually cause some trouble. It's like having a bunch of retired cells hanging around, stirring up mischief. That’s because these retired cells can start secreting all sorts of inflammatory molecules which can contribute to aging by disrupting tissue function and promoting inflammation.
Stem Cell Exhaustion
Stem cells have the incredible ability to divide and differentiate into different types of cells – whether it's a shiny new skin cell or a sturdy bone cell. They're like the body's own repair crew, constantly replenishing and rejuvenating our tissues to keep everything running smoothly.
But as we age, our stem cells can start to run out of steam in a process known as stem cell exhaustion. When the regenerative capacity of your stem cells begins to decline, your body isn’t able to repair and regenerate tissues as efficiently as it used to – upping the risk of age-related diseases and contributing to the overall aging process.
Altered Intercellular Communication
inside your body, trillions of cells are constantly chatting away, sending signals back and forth like a bustling city street. This communication is essential for coordinating all sorts of processes – from immune responses to telling cells when it's time to grow or repair. It's like a giant game of cellular telephone, where messages are passed along from cell to cell to keep everything in sync.
As we grow older, these lines of communication can start to get a bit fuzzy – causing a breakdown in cellular communication channels. This altered intercellular communication can disrupt important signaling pathways, leading to all sorts of trouble and triggering the signs of aging.
Immune Dysfunction
Your immune system is comprised of an army of cells, proteins, and other molecules standing guard, ready to fend off any invaders that dare to threaten your health. Your immune system tirelessly patrols your body to keep you safe from harmful bacteria, viruses, and other nasties.
But over the years, your immune system can lose its pep – becoming less effective at recognizing and responding to potential threats.
Inflamm-Aging
Your body is designed to maintain a delicate balance between inflammation (which helps fight off infections and heal injuries) and keeping things cool and calm. But as we age, this balance can start to tip, and inflammation can start to run amok.
And this chronic, low-grade inflammation, known as inflamm-aging is like a slow-burning fire – smoldering away and causing damage to tissues and organs over time. This persistent activation of the immune system and increased production of pro-inflammatory cytokines, can damage tissues, promote the development of age-related diseases, and exacerbate the aging process.
Tissue Degeneration
Throughout our lives, our tissues and organs work tirelessly to keep us ticking along. But as we age, they start to show signs of wear and tear in a process known as tissue degeneration – or the progressive deterioration of our body's tissues and organs.
Think of tissue degeneration like the foundation of a house starting to crumble – leading to all sorts of structural issues. Tissue degeneration can increase the risk of frailty, disability, and chronic pain, and it's a key contributor to the aging process itself. Plus, as our tissues start to break down, it can leave us more vulnerable to injuries and illnesses, making it even harder to maintain our vitality as we age.
So, How Can You Fight Aging? Powerful, Science-Backed Anti-Aging Strategies
While we certainly can’t stop the hands of time and the inevitable process of aging, that doesn't mean we can’t pump the brakes. You see, understanding these underlying processes that are the root causes of aging, means we can incorporate strategies to slow their impact and subsequently, slow the aging process. Here are some powerful science-backed strategies you can use to age gracefully and slowly:
Prioritize A Healthy, Balanced Diet:
The foods you consume quite literally become the building blocks for your cells. So if you want to pump the brakes on aging, it’s important to prioritize nutrients that will help your cells perform at optimal levels. That means building most of your meals around nutrient-dense foods like fruits, vegetables, lean proteins, and healthy fats. If you need help incorporating more healthy, anti-aging foods in your diet, be sure to check out my recipe library.
Up Your Antioxidants:
Antioxidants are molecules that play a crucial role in shielding your cells from damage that can accelerate the aging process. Maximize your antioxidant intake by incorporating antioxidant-rich foods (like berries, leafy greens, nuts, and seeds) and consider taking antioxidant-boosting supplements like Glutathione Essentials, Super Turmeric, or ResveraMax.
To learn more about the health-boosting, age-defying power of antioxidants, head over and read my blog What Are Antioxidants? And What Are the Health Benefits of These Incredible Compounds?.
Increase Autophagy
Autophagy (pronounced “ah-TAH-fah-gee”) is like your body's own tidy-up team. When cells find damaged parts or things they don't need, they wrap them up and break them down into simple pieces that can be reused. This clean-up process is crucial for slowing the aging process because it reduces the build-up of cellular damage and helps maintain overall cellular health.
Some of my favorite, tired-and-true ways to increase autophagy include:
- BroccoBoost: BroccoBoost contains a concentrated dose of sulforaphanes – powerful compounds found in cruciferous vegetables like broccoli. These mighty compounds enhance autophagy by activating cellular pathways that promote the clean-up and recycling of damaged cell components.
- ResveraMax: Resveramax is a unique combination of phytonutrients designed to stimulate a protein known as Nuclear factor-erythroid-2-related factor 2 or Nf2. This protein serves as sort of molecular switch that turns genes on or off and can have a major impact on regulating and increasing autophagy.
- RenUAl: Pure RenUAl contains a compound known as Urolithin A. Urolithin A increases autophagy by activating a process called mitophagy – a specific type of autophagy that targets and removes damaged or dysfunctional mitochondria from cells.
- Bergamot Plus: Bergamot is a citrus fruit native to Italy. Extracts of this powerful fruit can increase autophagy by activating cellular pathways that promote the clearance of damaged cell components.
- Super Tumeric: Turmeric and its active component curcumin can enhance autophagy by stimulating the expression of key proteins involved in the initiation and progression of the autophagic process.
- Coffee: Coffee contains a medley of bioactive compounds (like caffeine, caffeic acid, trigonelline, and chlorogenic acid) which stimulate cellular pathways involved in the initiation and progression of autophagy. My all-time top recommendation for coffee is Purity Coffee – their organic certified, specialty grade coffee is high in antioxidants and free of contaminants.
- Fasting: Another potent way to enhance autophagy is by fasting – abstaining from any food or caloric intake for a specified period of time. Fasting increases autophagy by depriving cells of nutrients, triggering cellular stress responses that activate autophagic pathways.
To learn more about autophagy and dive deeper into ways you can supercharge this remarkable process, head over and read my article Optimizing Autophagy: Could It Be the Secret to Better Health and Longevity?.
Be Mindful Of Exposure To Environmental Toxins:
Environmental toxins can contribute to the underlying mechanisms that cause the cellular dysfunction seen in aging. Minimize exposure to toxins by opting for natural cleaning and personal care products, using air purifiers indoors, filtering your water, and blocking harmful EMFs.
Minimize and Reframe Stress:
Chronic stress is like pouring gasoline on the slow-burning fire of aging – rapidly accelerating its destructive effects on the body. So it’s important to minimize stress, find healthy ways to cope with the unavoidable stress, and reframe pressure and responsibilities from a source of stress to a source of motivation. Click here to learn how to kick toxic stress to the curb and become stress-proof.
Make Sleep A Priority:
Quality sleep is essential for cellular repair, hormone regulation, and overall rejuvenation. Aim for 7-9 hours of uninterrupted sleep each night and be sure to practice good sleep hygiene (click here to check out my favorite all-natural sleep hacks). If drifting off to sleep feels like a far-off dream, you can also incorporate sleep-supporting supplements like Dream Powder or Sleep Essentials.
Prioritize Connection, Joy, and Laughter:
Your mental, spiritual, and emotional well-being are directly correlated with your health and longevity. As much as modern medicine tries to separate our body and our mind, they are one in the same – you simply can’t alter one without impacting the other. So be sure to prioritize connections with loved ones, pursue hobbies and interests that bring you joy, and embrace humor and laughter whenever possible.
Find Your Flow:
Another aspect of your mental and emotional well-being is feeling fulfilled and finding a sense of purpose. And one of the best ways to tap into these powerful feelings is by regularly getting into a flow state – a state where you are fully immersed and focused on the present moment.
Whether it's painting, gardening, or playing music, finding activities that challenge and engage you can promote mental acuity, creativity, and a sense of fulfillment – all of which contribute to healthy aging. Click here to learn all about what flow state is and how you can find your flow.
Connect With Nature and Practice Grounding:
There’s something about getting outside that is deeply healing and invigorating – physically and mentally. But it’s not just the fresh air and sunshine that is good for your well-being and longevity. You can also slow the sands of time by getting outside and practicing grounding or earthing – physically connecting with the earth's surface, such as walking barefoot on grass, sand, or soil, to absorb its natural energy.
Move Your Body
Our bodies are designed for movement – not sitting behind a desk, inside a vehicle, or on the couch all day long. And while our modern-day lifestyles may not allow us to move our bodies quite as much as we’re meant to, proactively engaging in regular physical activity can go a long way in combatting the effects of aging.
So take some time each day to move your body – even if it’s just simple stretching or taking the dog for a walk around the block. Or if you really want to get the most bang for your buck, you can incorporate whole-body vibration workouts which you can learn more about in my blog The Future of Optimal Health and Performance: Whole-Body Vibration Workouts.
Take Care Of Your Skin:
Your skin is your body's largest organ and serves as your primary barrier against the outside world. And that means your skin is often one of the first places to begin showing signs of aging.
Show your skin some love and protect it from premature aging by wearing sunscreen, moisturizing regularly, and using skincare products with antioxidants and hydrating ingredients to nourish and protect your skin barrier. Be sure to check out my all-natural, non-toxic skincare line designed with anti-aging in mind.
Keep Your Gut and Microbiome Healthy:
The health of your gut and the balance of your gut microbiome plays a pivotal role in aging – impacting just about every facet of cellular health and function that impact the aging process. So it’s crucial to keep your gut barrier strong and support a thriving, diverse community of microbes within your gut.
While all the above-listed strategies (like eating a healthy diet, minimizing stress, getting plenty of sleep, and avoiding toxins) have an immense impact on your gut health, sometimes it can be helpful to give your gut a little extra support. I recommend incorporating supplements like Gut Shield or Collagen Boost to beef up your gut barrier and a combination of Probiotics and Spore-Based Probiotics to reinoculate your gut with beneficial bacteria.
Ready To Slow the Sands Of Time and Age Gracefully?
While we may not have found the fountain of youth or have the ability to halt the aging process, understanding the process of how and why we age can help us slow its progression and enhance our quality of life. Prioritizing an overall healthy lifestyle and incorporating some of the anti-aging strategies listed in this blog can go a long way in helping us age gracefully and slowly.
And while we may not be able to do much more than slow the aging process from a physical standpoint, we hold the key to keeping our minds and spirits youthful. Embracing the journey of growth, change, and continuous learning allows us to defy the limitations of age and nurture a vibrant, fulfilling life.
If you’re looking for ways to age gracefully while cultivating a youthful, vibrant spirit no matter you’re age, I’ve got you covered. My entire body of work is focused on helping people just like you create well-being – physically, mentally, emotionally, and beyond. To get started on creating the healthiest, happiest, very best version of you – no matter what age – I recommend downloading my Resource Roadmap. It’s totally free and will connect you to the most useful resources for wherever you’re at in your journey – just click right here and access it now!
Resources:
- Hallmarks of Aging Part 1 of 4 (peptidesciences.com)
- Hallmarks of Aging Part 2 of 4 (peptidesciences.com)
- Hallmarks of Aging Part 3 of 4 (peptidesciences.com)
- The Hallmarks of Aging Part 4 (peptidesciences.com)
* These statements have not been evaluated by the Food and Drug Administration. The product mentioned in this article are not intended to diagnose, treat, cure, or prevent any disease. The information in this article is not intended to replace any recommendations or relationship with your physician. Please review references sited at end of article for scientific support of any claims made.
1 Comment
Some great info for those wanting to extend life/live better. I recently started taking Rapamycin. Although I heard about it for longevity from Peter Attia’s podcast I’m taking it to see if it might help my ME/CFS. A retired doctor reported on the Health Rising blog that it virtually cured him. I noticed on the Rapamycin site some others with chronic fatigue are also trying it after seeing the doctor’s blog article. If no help after a year will stop as who wants to live longer with CFS.
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