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New Study Links Trans Fats to Depression

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  3. New Study Links Trans Fats…
Consumption of trans-unsaturated fatty acids (TFAs or trans-fats) has been linked to a significantly increased risk for depression
January 28, 2011 — Consumption of trans-unsaturated fatty acids (TFAs or trans-fats) has been linked to a significantly increased risk for depression. On the other hand, olive oil, monounsaturated fatty acids (MUFAs), and polyunsaturated fatty acids (PUFAs) appear to have a protective effect and lower depression risk, new research suggests.

Spanish investigators from the University of Las Palmas de Gran Canaria found that compared with their counterparts who consumed diets low in TFAs, individuals with elevated levels of trans-fats had a 48% increased risk for depression.  These findings, say researchers, suggest cardiovascular disease and depression “may share some common nutritional determinants related to subtypes of fat intake.

“The results were not surprising [and] I think the message is clear: ‘try to eat healthy,'” lead study author Almudena Sánchez-Villegas, PhD said.  “Avoid some types of fats, such as trans and saturated fatty acids, and increase the intake of polyunsaturated and monounsaturated fat; it’s better to consume olive oil than margarine or butter, better to use low-fat dairy than high-fat dairy, and better to eat fish than to consume meat or meat products; avoid fast and processed foods and commercial bakery; and try to increase your consumption of fruits, vegetables, and nuts,” she said.  Following this advice, she added, will not only protect against cardiovascular disease but, as suggested by this and other recent research, also mental illness.  The investigators note that this is the first cohort trial to assess “such a broad spectrum of fat subtypes in relation to depression risk.”

“Depression affects more than 150 million people worldwide. However, relatively few [longitudinal] studies have analyzed the effect of diet on this disease,” said Dr. Sánchez-Villegas.  She added that several previous studies have suggested a link between cardiovascular disease and depressive disorders via inflammatory, endothelial, or metabolic processes.

“The adverse effects of trans-fatty acids on cardiovascular disease are thought to be mediated by increases in proinflammatory cytokines and endothelial dysfunction. We decided to analyze the possible association between trans-fatty acids and depression because low-grade inflammatory status and endothelial dysfunction are common among depressed patients,” Dr. Sánchez-Villegas explained.
“On the other hand, olive oil contains some bioactive polyphenols with important anti-inflammatory properties. This anti-inflammatory capacity…could also improve the function of the endothelium.”

“The finding regarding the [TFA] is of particular importance. There are no data that I’m aware of to date that have actually looked at its intake and risk of mental health problems,” said Dr. Jacka.
“I think this adds to the body of literature that’s been developing for the last 12 months showing that dietary factors are a potential real importance in both the risks of mental health and the progress of mental illnesses. And now we’ve got a little bit more information on specific nutrients.”

She noted that TFA is “a particular problem in the food chain,” especially in the United States since Americans tend to consume more TFAs than populations in other countries.

PLoS ONE. Published online January 26, 2011. Full text

* These statements have not been evaluated by the Food and Drug Administration. The product mentioned in this article are not intended to diagnose, treat, cure, or prevent any disease.   The information in this article is not intended to replace any recommendations or relationship with your physician.  Please review references sited at end of article for scientific support of any claims made.

Category: Brain HealthBy Jill Carnahan, MDJanuary 29, 2011Leave a comment
Tags: depressionfatty acidsmoodOlive Oiltrans fattrans fat depression
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Author: Jill Carnahan, MD

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Dr. Jill is Your Functional Medicine Expert! She uses functional medicine to help you find answers to the cause of your illness and addresses the biochemical imbalances that may be making you feel ill. She'll help you search for underlying triggers contributing to your illness through cutting edge lab testing and tailor the intervention to your specific needs as an individual. She may use diet, supplements, lifestyle changes or medication to treat your illness but will seek the most gentle way to help your body restore balance along with the least invasive treatment possible. Dr. Jill is a functional medicine expert consultant and treats environmental and mold-related illness as well

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Dr. Jill
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