Italian researchers treated 50 cranky, colicky infants with this probiotic bacterium (108 colony-forming units in 5 drops oil) or placebo for 21 days. At baseline, median crying time was 370 min/day for the L. reuteri group and 300 min/day for controls.
Three weeks later, the probiotic babies were crying a whole lot less—a median of 35 min/day versus 90 min/day in the placebo group. The number of infants with at least 50% reduction in crying time was much higher in the L. reuteri group (Savino F, et al. Pediatrics 2010 Aug 16 early online).
In a previous study, this probiotic out-performed the anti-colic drug, simethicone (Savino F, et al. Pediatrics 2007 Jan;119(1):e124).