“Leaky Gut” Syndrome
Leaky Gut – The Syndrome Linked to Many Autoimmune Diseases. Hyperpermeability or “leaky gut” syndrome is the name given to a very common disorder in which the cells lining the intestines become “leaky” due to inflammation. The abnormally large spaces present between the cells of the gut wall allow the entry of toxic material into the bloodstream that would normally be eliminated.
The gut becomes leaky in the sense that bacteria, fungi, parasites, undigested protein, fat and toxic waste normally not absorbed into the bloodstream in the healthy state, pass through a damaged, hyperpermeable gut membrane. This can be verified by special gut permeability urine tests or microscopic examination of the lining of the intestinal wall.
Common Causes of Leaky Gut
- Infections – fungal overgrowth, parasitic infections
- Drugs like
- NSAIDS, chemotherapeutic agents
- Crohn’s disease or Ulcerative Colitis
- Celiac disease
- Chronic alcoholism
- Strenuous exercise
- Food allergies
Leaky Gut and the Connection to Autoimmune Disease
Leaky gut syndrome is almost always associated with autoimmune disease. In fact, reversing symptoms of autoimmune disease depends on healing the lining of the gastrointestinal tract. Any other treatment is just symptom suppression. An autoimmune disease is defined as one in which the immune system makes antibodies against its own tissues. Diseases in this category include lupus, alopecia areata, rheumatoid arthritis, polymyalgia rheumatica, multiple sclerosis, fibromyalgia, chronic fatigue syndrome, Sjogren’s syndrome, vitiligo, thyroiditis, vasculitis, Crohn’s disease, ulcerative colitis, urticaria (hives), type 1 diabetes and Raynaud’s syndrome. Fortunately doctors are beginning to realize the essential role that the gut plays in these disease. Understanding the leaky gut phenomenon helps us see why allergies and autoimmune diseases develop and how to design therapies to restore intestinal integrity and reverse leaky gut.
Inflammation is a key trigger for leaky gut
Inflammation causes the spaces between the cells of the gut wall to become larger than usua. Then protein molecules are absorbed before they have a chance to be completely broken down. The immune system starts making antibodies against these larger molecules because it recognizes them as foreign, invading substances. Antibodies are made against these proteins derived from previously harmless foods. The immune system becomes hyperstimulated and over-reactive to substances that are not necessarily supposed to be dangerous.
Human tissues have proteins & antigens very similar to those on foods, bacteria, parasites, candida or fungi. The antibodies created by the leaky gut phenomenon against these antigens can get into various tissues and trigger an inflammatory reaction in that tissue when the corresponding food is consumed or the microbe is encountered. Autoantibodies are thus created and inflammation becomes chronic. If this inflammation occurs in a joint, autoimmune arthritis (rheumatoid arthritis) develops. If it occurs in the brain, myalgic encephalomyelitis (chronic fatigue syndrome) may be the result. If it occurs in the blood vessels, vasculitis (inflammation of the blood vessels) is the resulting autoimmune problem… and so on.
If the antibodies end up attacking the lining of the gut itself, the result may be colitis or Crohn’s disease. If it occurs in the lungs, asthma is triggered on a delayed basis every time the individual consumes the food which triggered the production of the antibodies in the first place. It is easy to see that practically any organ or body tissue can become affected by food allergies created by the leaky gut. Because the foods can trigger delayed reactions, it can often be very hard to pinpoint the triggering entity.
Leaky gut may cause increase risk of infection and sensitivity to environmental chemicals
This ongoing inflammation also damages the protective coating of antibodies normally present in a healthy gut called IgA. Since IgA helps us ward off infections we become less resistant to viruses, bacteria, parasites and candida. These microbes are then able to invade the bloodstream and colonize almost any body tissue or organ. In the clinic we often find patients with leaky gut or autoimmune disease also have microbial infections ongoing in the gut.
Not only can leaky gut create food allergies as the proteins we consume are activating antibodies, but the microbes in the gut can cross over into the blood stream creating a toxic burden that overwhelms the liver’s ability to detoxify. Often in severe cases of leaky gut, patients will develop sensitivities to perfume, cigarette smoke or other environmental chemicals. Common complaints are also “brain fog”, confusion, poor focus/concentration, or memory loss.
Leaky gut also causes malabsorption and nutritional deficiencies
Finally, leaky gut may contribute to a long list of mineral deficiencies because of the ongoing inflammation and damage to carrier proteins. The most common are iron deficiency, vitamin B12 deficiency, magnesium deficiency which can lead to fatigue, neuropathies or muscle pain. Zinc deficiency due to malabsorption can result in hair loss or baldness as occurs in alopecia areata. Copper deficiency can occur in an identical way leading to high blood cholesterol levels and osteoarthritis. Further, bone problems develop as a result of the malabsorption of calcium, boron, silicon and manganese.
Do you believe leaky gut can be caused by fluoroquinolone toxicity?
Since all antibiotics have the potential to disrupt intestinal microflora and an abnormal microbiome may contribute to increased intestinal permeability, yes, but this effect would not be limited to fluroquinolone antibiotics…
What type of diet would you recommend to people suffering with leaky gut due to candida overgrowth, while also suffering with Hashimotos?
By healing the gut, can this reverse activated natural killer cells?
Hi Lori, Read this article for tips on treating candida with diet – http://www.jillcarnahan.com/2014/05/16/6-signs-sibo-might-root-cause-ibs/ You should eliminate all grains and sugars, alcohol and yeast at the very least.
Hawaiin spirulina and moringa
Kills candida + allergies + diabetus + high blood pressure
I feel great
I wanted to Pin this article but your PinIt link does not work.
Thanks for an excellent article!
We’ll fix this, Heidi!
I’ve lost weight (10 # in 5 yrs). By trying to gain, I’ve been on a carb diet, now my Practicioner says “no carbs” .thinking that I have a yeast infection and do not absorb nutrients. I think I may have leaky gut and don’t know what to eat if I leave off dairy and grains. I’m afraid that I may lose more weight. Symptoms: chronic fatigue, brain fog, yellow skin with keratosis and flat warts on forehead and in the corner of my eye, cold intolerance.. I’m 72. Had breast cancer 14 yrs. ago, now Supraventricular tachycardia taking Diltiazem 120mg., also, Simvastatin 10mg. I really have so much trouble with my digestion and don’t know what to eat. I know that wheat and dairy bother me. I cannot get regular. Mostly have loose stool and gas. Please help. Thank you so much.
Hi Janet,
Please find a trained functional doc in your area to help you determine if there are any microbial imbalances or digestive issues that is causing you to have trouble losing weight. You’ll want to have him/her check for pancreatic insufficiency and low stomach acid as well as any infections.
Hi Jill,
I am a 64 yo male who was diagnosed with Sjogren’s Syndrome six months ago. From my reading it seems that leaky gut may be implicated in all autoimmune conditions, so I am interested in taking the approach of assuming that I have leaky gut and doing something about it. I am atypical inasmuch as I have led a pretty healthy lifestyle most of my life. I have never been a smoker, drinker or drug user, and I have not eaten junk food (sweets, ice-cream, cakes, sugary biscuits etc.) since 1976.
I have been vegetarian since the mid eighties, and I eat a large amount of raw food (but not to the exclusion of cooked food). I eat a few eggs daily, and have started eating a fair bit of yoghurt lately as well. I am going to buy some live cultures and make my own yoghurt from A2 milk so that I can feel confident that I am getting the real deal. I also intend to start making fermented foods for the microbial benefits that that approach entails.
I have never been overweight in my life and I lead a reasonably active life in terms of exercise.
My main symptoms from Sjogren’s Syndrome are the typical dry mouth and eyes (although not to a debilitating extent), and a feeling of weakness in my legs and arms, which it seems is not such a typical symptom.
My question is this: what suggestions would you make in terms of diet and lifestyle for someone in my position, given that I am not going to be consuming meat or fish or bone broth, or any other approach that would compromise my vegetarian status?
Thanks for listening to my life story. 🙂
Hi Adrian,
You are in a difficult situation as I find it very hard to treat autoimmune disease in patients unwilling to at least consume eggs and fish. I would hope you are the exception to the rule for your sake but since healing a leaky gut often requires eliminating gluten, dairy, soy, corn any refined grains, and legumes in some cases (those who are sensitive to lectins), there is just not enough foods left to survive on without adding some healthy fats, like coconut, ghee and proteins, like fish and eggs. You might start by doing an IgG food antibody profile which will steer you away form foods you are most sensitive to. I wish you health and healing!
warmly
Dr Jill
Hi Adrian, I was wondering 16 months later how the progress is with combating Sjogrens?
Hi again Jill,
Thanks for your timely reply. As I said in my original blurb, I do in fact eat eggs. I have three eggs with my evening meal, which is usually, but not always, a large plate of raw vegetables followed by a large helping of sweet potatoes. Sometimes I might eat additional eggs during the day as well, so my egg consumption is actually considerably in excess of the amount that most carnivores would eat. 🙂
I am now having two glasses of vegetable juice per day…carrots, celery, broccoli, beetroot, cabbage, cauliflower and capsicum, along with a teaspoonful of flaxseed oil to assist absorption of the carotenoids.
I have at least one apple and one orange per day, and have been eating a fair bit of yoghurt lately, which may have to go in any elimination diet, but perhaps I could make yoghurt using coconut milk or some other non-dairy alternative.
Thanks for your input,
Adrian.
Hi there. I have been suffering with chronic symptoms for the last 2 years – fatigue, rashes, twitching, sinus issues etc. No conventional doctor could diagnose. I saw a functional medicine doctor and the only things that were found was that I had little to no strains of good bacteria in my gut. However, I’ve been on paleo with probiotics, coconut products, green juices and other herbal supplements for 2 weeks and so far have felt no different whatsoever. What are your suggestions? (I’ve tested for gluten sensitivity, stool test found no parasites, yeast, bad bacteria etc). Please help!
Hi Jonathan, you should have your doctor test you for other infectious diseases, including borrelia.
Great reminder Jill, For those like Janet who have a malabsorption issue and can not maintain weight coupled with brain fog the brain/gut axis may be impaired. In our clinic we start supplementation with DHA/EPA transdermally every day to calm the inflammation both in the gut and the since Omega 3 cross the blood/brain barrier. As Jill Has pointed out in another wonderful article , coconut oil is a great way to clean up a yeast problem.
Hi Dr. Carnahan,
I have chronic fatigue/fibromyalgia and now pre-lupus. My son (10 years old) has chronic fatigue/fibromyalgia and my aunt has chronic fatigue/fibromyalgia/lupus. My son and I have been receiving treatment for 3.5 months antibiotics (low dose azyithromyocin 500 for my self and 250 for my son, 3x/week), supplements and immuno boosters. We have improved significantly. My son and I tested positive for EBV, Mycoplasma pneumoniae and Chlamydia pneumoniae. I also have HHV6, Coxsackie 3 and 5. My aunt has not been tested but has had EBV. Her “lupus” has gone to her lungs and she has had several surgeries on her intestine (due to blockages and adhesions), her latest to “restructure” what was left of her colon to prevent a bag–she was told she could “not afford another blockage”. I would like to get her tested and treatment started. What is the best way to proceed? I am worried about Herx reactions (with her lungs), dexot and absorption with her gut as well as blockages. Where to begin? She lives in a remote area in Utah—The closest functional medical doctor is in another state–she is too fragile to travel. any help would be appreciated. thank you! Lori
Hi Lori – I will email you with some information that you might find helpful to your aunt.
warmly
Dr Jill
What is your recommendation for finding a reputable functional medicine doctor? I tend to like the very natural approach and am concerned about finding someone who is trust-worthy and thorough
Hi Schenley – you can search by zip code for functional medicine trained physicians at http://www.functionalmedicine.org
warmly
Dr Jill
So a leaky gut can develop into an Autoimmune Disease? Wow! My daughter has been told she has lupus, syjorgen’s syndrome, rheumatoid arthritis, and she can’t tolerate wheat products. She is considered a chronic pain patient, had to have a pacemaker put in to assist with a stronger heartbeat, since the lupus started attacking her heart. She uses a cane to walk because she had to have discs in her spine replaced, and has difficultly walking. It seems she takes every pain medication out there, from oxycodone, morphine, methotrexate, gabapentin, etc, etc. Doctor’s have told her that’s all they can do. Although she is in constant pain, she always tries to stay in an upbeat mood. How would she find out she has a leaky gut? She can’t work, is on disability, I try to help but I am recovering from breast cancer myself and can only help so much. Is there a book, a test, a place, something that could help pinpoint this affliction that is slowly robbing her of life. She is 40, but seems 60-70most days. I really am pulling at anything that may at least help her to not be in so much pain. Thank you for reading this.
Hi Lori I was bitten by a lyme tick about 20 years ago but it was not found for about 15 years I have gone through IV antibiotics for 1 year with no probiotics. After my picc line came out on its own for the second time I had it pulled out.prior to this treatment I had extreme exhaustion and flu like feeling as well as foggy head. The exhaustion and foggy head has continued even after seeing a functional med Dr for about 2 years receiving iv’s for my digestion issues I could not afford to stay with him as my insurance would not cover much if any of the fees. I know see a PA that has helped me especially with my hormones as I am 53 now and have gone through menopause but I am still battling the fatigue daily. I have been food allergy tested and know the foods I need to stay away from and have gotten away from it the last year due to lots of other stress in my life but just recently I have gone back on the candida diet. I also should add about 18 years ago I had bariatric surgery thinking it was my weight that was making me so fatigued I lost 100 lbs but have gained back about 40 lbs due to no energy and lack of exercise. If you could help me in any way I sure would appreciate any information this has absorbed almost half of my life and I would like to enjoy my golden years with my saint of a husband!! Thank you so very much
Hi Tammy – yes ALL autoimmune disease has leaky gut and intestinal permeability as part of the trigger…
best in healing
Dr Jill
hello! I was found with autoimmune desese they tested me for lupus and RA and both came negative. They reffered me to a reumatologyst but i know that i am not going to take painkillers and immune surpressant. My question is do I still have to go and discover what exact sickness i have before going with functional medicine doctor or i can start my healing without it? The only FM doctor in my area is a general family Dr. I didnt go yet because the office is far from where I live and i dont have a car. I dont want to make the dr to loose time with me going without needed information
Thank you!
Hi Yulia,
No, you do not… functional medicine looks for root cause of your symptoms and having an exact label on your autoimmune disease will not change a functional medicine approach to search for the root cause
warmly
Dr Jill
Hi! My daughter has asthma, reacts to pets, reacts to lotions and other chemicals, and many food sensitivities. Is this leaky gut?Any thoughts on how to heal her gut?
Hi Holly
Multiple chemical sensitivity is a sign of toxic overload. That can be from internal trigger like food allergies or leaky gut or from external toxic exposures. Best to get a functional medicine doc and start with comprehensive stool testing and urinary organic acids to determine the cause
warmly
Dr Jill
My son was told he has chronic gastroenteritis and we’ve had non success with medicine. Taking him to his PCP on the 7 the .I believe it could be something else. He’s in pain when he eats he looks and acts like he’s going to get sick for about thirty minutes. Rice is one thing his stomach can handle. What should I tell the doctor tontest him for?He also has neurofibromatosis one.
Hi Kim,
Get a functional medicine doc to order comprehensive stool testing and organic acids. You also might want to have him tested for IgE and IgG food allergies
warmly
Dr Jill
Thank you for this article. It puts into words what we’ve been figuring out over the last few years with my son, and I’m beginning to think with myself and my autoimmune disorders, as well. This will help me be able to explain it to others as well. We’ve taken out foods he’s sensitive to and worked on gut health and we’ve seen truly amazing results. Thank you!!
Great article except for adding the parenthises after Sjögren’s Syndrome.
Sjögren’s is so much more and some of us who suffer with it would almost call your reference to dry eyes & mouth offensive. Some Sjögren’s patients do not have difficulties with either. There are much bigger struggles involved.
Thanks for the information on leaky gut. I’m sure it will be quite benificial.
Hi i have ankylosing spondalitis and have thought for a while now i have leaky gut as I’m gluten intolerent as well now. since cutting gluten completely out of my diet i have no pain from the arthritis but my tummy is very sensitive, i was told by a naturopath to start on L Glutamine powder, a digestive vitamin and a parasite cleanse and i have not had any tummy problems since being on this in 4 weeks. I still consume a small amount of dairy in the way of cheese and organic or raw milk. Can you tell me how long it takes to heal the gut?
Hi Natasha,
There is no one-size-fits all and gut healing can be months to years. It’s all about finding triggers, such as microbial imbalance, pathogens, etc and removing them, then working at restoring normal gut integrity.
warmly
Dr Jill
Can a leaky gut cause ovarian adhesions as well?
I suspect this is not common but intestinal inflammation could cause adhesions in the peritoneum that affect other organs
Hi Jill,
What a wonderful & informative post!
I was hoping you would have also mentioned the best & most effective ways you’ve discovered to heal a leaky gut. Is there another post or article of yours you could please direct me too with this info?
I have severe Multiple Chemical Sensitivity & have also been on a strict mono rotation diet for over 2 years (5 core foods) & minimal supps on rotation too. Pancreatic insuffiency too.
Many thanks for your kind reply.
Regards,
Amelia
Hi Amelia – Check out Part II here!
Hi Jill,
For most of my life I have been healthy but have always had joint aches and pains on and off. In the last five years these have become more problematic with swollen finger joints and stiffness etc and now I can’t make a fist as fingers are becoming misshapen. I was referred to a Rheumatologist and diagnosed as having Psoriatic Arthritis ( only ever had one attack of ?Psoriases) At first I was given Methotrexate which caused liver function and kidney function problems so was taken off this medication and given Sulfasalazine and as they didn’t work eventually added Hydroxycloroquin 200mg daily. Still no change to my symptoms but I have developed a problem with the mucous membrane of my mouth which is similar to Candida but I have been told by my doctor and a specialist that it is not Candida! I have just had two very painful biopsys taken from the inside of my mouth and awaiting results! No one has ever mentioned leaky gut syndrome to me! I would appreciate your opinion on how you think I should manage this problem in the future. I have had the mouth condition for 18 months now so I am concerned about not to mention the discomfort it is causing me. Also I play Ukulele in a Band so need to keep as much mobility in my hands as I can. I am already having quite a lot of difficulty hitting some chords!
Hi Alice,
Please find a functional medicine physician to help you test and treat the underlying causes to your symptoms. Due to the oral ulcerations, it is quite possible you have dysfunctional sIgA or infections.
warmly
Dr Jill
I need help. I’ve been in bed since December 2012 after a flu vaccine destroyed my body. I have been on a mission to find what’s killing me and along the way found, Lyme disease, non-existant gut flora, reactivated Epstien-barr virus, cytomegalovirus, c. Pneumoniae, mycoplasma pneumoniae, parvo viruses, low vitamin d, low cd-57, positive ANA, and a few other abnormalities.
I feel like I’m dying 24/7. My daughter and husband both also tested positive for Lyme. Husband has EBV too.
Main thing you may be able to help me with is… Pain in a specific location. It’s in my right abdomen area in the very bottom floating rib and radiates internally into my back. It causes “fainting” feelings when I’m sleeping and is killing me neurologically faster than anything else. I’m on gabapentin and it isn’t helping. I’ve taken hydrocodone only once and spent the night on the sofa convulsing and in a horrific state. I’ve also tried tramadol and it did nothing. What could be causing this pain??? It isn’t my galbladder and my blood work looks fine.
Also, any advice on how to re-grow my beneficial flora? I think the flu shot killed it or caused a yeast overgrowth. I tested negative for yeast, but I’m in such pain. Thank you!
Hi Amanda,
As you can imagine, I cannot diagnose over the internet. You should get a functional medicine doc in your area to help you by testing more thoroughly with a stool analysis (Genova GI Effects) to check for imbalances. Some patients with yeast overgrowth or SIBO may have a negative stool test as well.
warmly
Dr Jill
The GMO variety BT which releases a bacterium (that the plant internally manufactures) that causes the stomach of the insect to inflame to the point of rupture is legal for both humans and livestock to consume. It seems more than likely that this same micro process is occurring in the guts of larger consumers of the BT modified crops. Thoughts?
Hi Jill,
I’ve had back pain for years and also chronic gut issues. Recently I had a colonoscopy and ulcerations in my LB indicated Chrons. To be sure there was nothing further up in SB, my gastroenterologist sent me off for a CT scan which came back indicating that there was Ankylosing Spondylitis in my spine (my sacral joints already fused apparently). I’m guessing that leaky gut is the likely ground zero. I’m hoping you may have some information or link whatI can do to rectify my gut and get off the immunosupressants (sulfazine or something) I’m currently on to dampen the inflammation and ulceration? I’d appreciate any advice. 🙂
Thankyou
Please read part II regarding diagnosis and treatment of leaky gut.
My son has regurgitated food for almost two years now. He’s had an EGD done that showed no sign of acid reflux, he’s tried prilosec and it does nothing, tested negative for celiac and negative for esophogitis. ..
we tried gluten free and didn’t notice any change in him. He says he just feels like he has to burp…sso he does and food comes up..iit happens several times after meals and in between meals…bbut majority of times happen within an hour after eating, regardless of what he eats. He doesn’t drink soda much..uusually only water and milk. Eats a wide range of foods not a lot of sweets but once in a while as a treat. He’s 8 years old. there are other tests drs want to do but I’ve said no because they have indicated the tests are just to see if acid is present when he has symptoms…aand if it is…tthey would recommend prilosec..which we have already tried that and it had no change in symptoms and I don’t want him on that. Suggestions?
Hi Jamee,
I suggest finding a functional medicine pediatrician that can test him for microbial imbalances in the gut and treat. He may need some type of elimination diet and I highly recommend at the least a trial off gluten, corn, soy, dairy, egg, sugar and peanut the top allergens.
blessings
Dr Jill
My daughter found help with NAET – Nambudripad’s Allergy Elimination Techniques -for her leaky gut, fatigue and food allergies. By eliminating her allergies one by one, her gut healed and she is able to eat all foods again – including gluten. Her energy is restored. The treatments are noninvasive, no pain, and no drugs.
Hi Dr Jill,
I have aleopecia areata for 6 years now. When I first got it all my hair had fallen out completely. After getting cortizone shots my hair came back. I have been maintaining it with the shots 4-6 weeks ever since. But there are times where my aleopecia is more aggressive than others. It seems like in the fall and winter I lose more hair. This winter I lost about 50% where as in the summer I went a few months with only small patches. I eat healthy, very limited junk food, alcohol, and sugar. I eat lean meats, natural foods, fruits and veggies, I no longer eat any processed foods from a box. I exercise regulary, and take vitamins. My question is, being that I have a leaky gut, why is my aleopecia in like a cycle where it is ok and my hair is not falling out and it’s growing back one season then falling out like crazy the next? My diet is the same. I have recently been limiting the amount of wheat gluten in hopes that that would help. I eat eggs and nuts every day. What can I do to fix my leaky gut. I want so much to be cured and not have to get those shots or worry about losing all my hair again.
Hi Dawn,
I recommend not only limiting gluten but avoiding it 100% if you have gut issues and alopecia. You should also get a comprehensive stool test to determine if you have any pathogens or micribial imbalances contributing. The Genova NutrEval would be a good test to determine if you have any nutritional deficiencies contributing.
warmly
Dr Jill
Hi,
My 5 year old poops are totally off. When I bring it up to the pediatrician, they act as if this is normal. It definitely does not look normal to me… it looks like a normal S shape at the beginning, but ends in a huge pile of mush at the end and it takes a ton of toilet paper and wipes to clean him. Can you help direct me to where I should research or get help? Thanks!
Hi Mara,
Find a functional medicine trained pediatrician and get a stool test to determine microbial balance in the gut. That would be a great place to start. I use Genova GI Effects testing.
warmly
Dr Jill
My son had asthma as a little guy (2-6) which mostly resolved. It seemed to be triggered environmentally – dust, basement, still occasionally with cats.
He now has type 1 diabetes – diagnosed last year (May 2014) at age 9.
I do not know of digestive issues, but know he will be tested for auto-antibodies for Crohns due to the T1D (they tested on diagnosis for some). He is still in honeymoon period with a reduced carb (but not restrictive on carb) diet. I have had him on Krill/Fish Oil for a few years due to his asthma sensitivities. Last year jan 2014 I started him on a 10 strain probiotic because he had a rash in groin area which spread up to stomach and his eczema at inner elbows had gotten worse. I thought it was candida related, I guess, and when it cleared up and he started losing weight, I gave the probiotics some credit… until he lost so much I began to suspect T1D… (he had been maybe 10 lbs overweight, but quickly lost more than 15 over a 2-3 month period)
With T1D as my “only” or at least “main” autoimmune component, what do you suggest pursuing? Leaky gut? What testing should I advocate for? What kind of doctor will be open to this? I see the link in the comments above: http://www.functionalmedicine.org Is that a place to start?
Thanks for any suggestions.
Yes, please find a functional medicine trained doc in your area do do specific testing and determine the root cause and gut imbalances that may be contributing to his symptoms.
Best of luck in healing
Dr Jill
My child has vitiligo. We were told it is an auto immune disease and no cure. Also she has keritosis. Could leaky cut be the cause and do you have any findings I could see on that?
Yes, it is possible
My lil girl has vitiligo and food allergies. I have taken her to many doctors including Naturopathic doctors and chiropractors. She tested positive for many food allergies. Was told she has a selenium deficiency. She was told to stay off of food offenders and put on probiotics and selenium and vitamins. Her skin cleared up some for awhile but now has gotten worse than ever. We did gradually add some of the foods back in her diet as we were told to do. It is so hard to keep a child off of so many foods. Is there anything else we can do for her? Please help.
Foods are not the enemy but when you still have ongoing permeability issues, she will continue to react to foods. You must find imbalances and heal the gut first.
Dr Carnahan,
I’ve had multiple health issues plaguing me for the last five yrs., none of which I’ve had any success with typical AMA treatments / doctors. In fact, I’ve diagnosed my self with hyperparathyroid disease and cervical dystonia in which I’ve had treatment and surgery on both of these. Now I have Esophageal Cancer with EoE. I believe that this is all stemming from my gut. Years ago I started following Dr Hyman and realized this is the way I want my medical issues addressed, unfortunately I live in Florida, and I feel I know more than the three functional medicine Doctors I’ve seen. All that I did was waste money on cabinets of vitamins, days of IV treatments and whacky medicine advice ( eat nothing but strawberries for one month and your cancer will go away ) I still believe in functional medicine but want someone to do a real profile, stool samples, address acidity, my food allergies and dive into my GI problems. I’ve followed my ALCAT, my IMMUNO LABS, and LEF food allergy test for a yr each at a time, no relief. I’ve done toxicity testing through METAMETRIX and GENOVA. Nutritional deficiency testing through SPECTRACELL and still got no where with all these doctors. If I ask my oncologist or my surgeon on any of these issues they dismiss it immediately, they don’t believe in gluten sensitivity, leaky gut, just steroids and other harmful medications. As far as my autoimmune issues I’ve been diagnosed with UMCTD in wich my rheumatologist wanted me on drugs I refuse to take ( biologics ) I love what you and Dr Hyman stand for, but where do I go for this here in Florida? I feel defeated, by both types of doctors.
Sincerely,
Tracy
Hi Tracy,
You can find qualified functional medicine trained docs by searching at http://www.functionalmedicine.org
Best
Dr Jill
Hi Dr. Jill,
My wife has psoriatic athritis and ulcerative colitis. Based on her symptoms (frequent headaches, fatigue, depression, anxiety, gets colds/viruses one after the other, difficulty losing weight), and the linkage you describe in this article it seems she has leaky gut syndrome.
Her Dr. told her that her colitis cannot be helped by diet which has made her feel pretty helpless. What therapies/diet can she follow to ease her symptoms, even if it doesn’t necessarily cure everything?
Thank you,
Mark
Someone once told me 12 years ago after my diagnosis of Crohn’s disease that “diet has nothing to do with it”. I refused to believe it and went on to cure myself from Crohn’s disease! Diet has everything to do with a healthy gut! Here’s a starting point….How Elimination Diet Can Change Your Health.
My 11 year old son has an IgA deficiency diagnosed when he was around 6. He has many environmental allergies (not food allergies diagnosed) and is currently on his 3rd year of allergy shots with good success. All of his life he has suffered with chronic constipation and has been on miralax and now the latest is biscodyl. While he never has the hard stools, he frequently has major gas, and explosive stools, that go from somewhat formed to liquid. I am concerned how this long term treatment is really affecting his gut health and whether or not his IgA deficiency is perhaps playing a role. What are your thoughts.
Yes, IgA deficiency will play a role in these symptoms and high association with gluten-sensitivity and celiac disease so I do recommend a gluten-free diet.
Hi I live un Dublin Ireland lupus raynauds arthritis fibromyalgia tried everything tried functional medicine sll she done was an elimination diet n no goodfood fir a week replaced by shakes stool test paid 1300 euro no bettet rashes sll over cholesterol high no iron bowel n rectal psinpain for 20 yrs n stomach I truly believe because this wasn’t addressed I ended up like this I’m so sick fir two yrs now please advise what to do thank you.x
I am sorry to hear that, Grace! Please find another functional medicine doc to help you.
warmly
Dr Jill
Do you think someone with an auto-immune disease like Rheumatoid Arthritis, can cure leaky gut? If so, how?
Yes, indeed! See my Part II article here
any relationship between leaky gut and ideopathic (so far) peripheral neuopathy……lots of blood work…all with negative results……
That would not be common
Hi
Why is’nt zonulin mentioned at all when checking for leaky gut? Increased levels of zonulin > increased gap between the tight junctions. It’s just a simple blood sample
HI Emil,
It’s because I have a entire blog article on it! Quite important… Here is the link
Dr Jill
In August,2014 my hair all fell out in a week. Diagnosed with alopecia, eventually lost all hair on my body. Eye lashes and brows are now gone too. Alopecia Universalis. All tests are normal, tried many treatments, hair began to grow back with azothiprine, but liver levels were high so stopped.
I feel fine ! Just miss my hair. I have never heard of leaky gut. I am 64, retired and workout 3 times a week with a trainer.
Any suggestions?
Hi Heidi,
It could be autoimmune related or other causes. If your hair loss is related to autoimmunity, I do suggest testing the gut with a functional medicine doc.
warmly
Dr Jill
Could Guttate Psoriasis be caused by leaky gut?
yes, indeed!
I am surprised to see that the GAPS protocol is missing from your list of treatment options. Go to http://www.gapsdiet.com/ to find out more. Get the book and read it ASAP! There is so much you can do to help the body heal if you give it the right conditions. Everyone with leaky gut should read Dr. Natasha’s book and get started asap…before the damage gets too great that you don’t have the energy to do what it takes. This protocol was developed (and her book was written) based on research and proven methods – she’s a neurologist who explains the gut/brain connection.
Hi CD,
I know all about the GAPS diet and use in clinical practice. There is no one-size-fits all and GAPS is one of many dietary interventions that works for some patients but not others. It really depends on underlying root cause.
warmly
Dr Jill
Could leaky gut cause EoE?
yes, absolutely!
I have a 9 year old boy with severe sudden-onset Raynaud’s and positive ANA antibody indicative of Connective Tissue Disease. It began in the tip of one finger in October and a couple toes for a few minutes. Within 2 weeks it was both hands and feet several times a day. The severity prompted Dr’s to put him on blood pressure medication (Nifidipine) but the results are not great. Since it’s an adult medication, there is no dose for a boy of his age and size so we do 2 5mg pills a day. Since beginning the medication, he’s had a constant sore tummy. The hospitals and doctors I’ve seen are not addressing this the way I feel it needs to be. Find the cause and reverse it. They are content waiting for more symptoms to appear. Which essentially is just waiting for it to progress. The emotional toll on him is heart-breaking. He’s missing sports and recess and this otherwise cool, confident, smart kid is doubtful, scared and upset. He’s so fatigued. Every day. I feed my kids well. Very little processed food, eliminating (most) gluten and only a small amount of dairy, a couple times a week when he feels like a bit of cereal. I am quite alone in my fight for him as I look for the answers. I am aware of the gluten /auto-immune connection, but somehow I seem to know more than the doctors in regards to this. I think your article explains it better than anything I’ve read and intend to reference it at the hospital. They want to give him more pills to settle his tummy, help with fatigue. I treat with real food, but with so much information out there, I feel overwhelmed and am not sure if I’m doing all that I can. Should I be taking him off all gluten, dairy, sugar, soy & corn without testing being done? He’s so stressed, I do allow him to have some because I’m so worried about his mental health. And those ingredients seem to be in everything. And immune-boosting foods – is that harming him since his immune system is in overdrive already?? He is hobbling every morning with both feet so numb and hurting and I hold his toothbrush for him because his fingers are numb. I have to help him get dressed when that happens at the time of getting ready… It’s all too much, no matter what kind of super-mom people seem to think I am. I would appreciate any sort of light on this. Many thanks and sincerely from very worried parents in Hamilton, Ontario Canada
Hi Jenn,
As you know from reading the gut and immune system are intricately connected and I always start by assessing the gut for hidden imbalances in the microbes or infections as triggers to autoimmune disease. I suggest searching for a functional medicine doc in your area to do some testing on your son and determine the underlying cause of the Raynaud’s (www.functionalmedicine.org) In the meantime, I would certainly recommend a 30 day trial elimination diet off the top 7 culprits (gluten, dairy, egg, soy, corn sugar, alcohol) and see if he improves. As hard as this may be, if he gets better it will be worth it! See my instructions on that here
Blessings,
Dr Jill
Please read this amazing article….
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945755/pdf/ITX-6-159.pdf
Yes, a classic by Dr. Seneff and personal favorite of mine! Thanks for sharing..
Dr Jill
Hi Jill- I am a 55 year old woman who has had “IBS” for 35 years. You can guess how many doctors I’ve seen. Diagnosed with Colitis 7 years ago, Fibromyalgia before that. Had my Gall Bladder out. Symptoms go on. I went vegetarian, then vegan. Some help, but not much. No help from Drs. besides wanting to push meds. 1 year ago I went on a juice fast for 30 days and felt amazing! IBS gone after 3 days. Went back to my regular diet after the fast and everything came back. So disappointing! So I started searching and thought to cut out all gluten. It WORKED! I am now on a juice fast to “clean out” all the toxins but need some medical support.
So my question is- why didn’t one doctor think of testing me for gluten sensitivity? Can I still get tested (even though I know the answer) for it?
My next question is how do I find a doctor with a practice like yours near me?
Hi Laverne
Yes, you can ask your doctor to test you for BOTH celiac disease (TTG IgA, IgA, anti-deaminated gliadin antibodies) and also the HLA typing (DQ2 and DQ8) genes for celiac. Both can be done through Prometheus or LabCorp. And you may search for a functional medicine trained doctor in your area at http://www.functionalmedicine.org
best in healing
Dr Jill
Can allergy medications like Zyrtek also further add to leaky gut? I am wondering about many things like this now. Really struggling to get IBS under control and I think leaky gut is part of it.
Hi MaryEllen,
Histamine creates increase intestinal permeability so it is likely that lowering histamine levels can aid in healing the intestinal lining. If you have IBS symptoms, you likely have SIBO or SIFO, which you can ask your doctor to test you for with stool and breath testing.
warmly
Dr Jill
Hi, Just wondering the implications for lymphocitic colitis, depression/anxiety, asthma, and chronic allergies? Thanks, Carla
yep! leaky gut is part of all the conditions you listed in most cases…
My son 6 years old has vitiligo in his finger since 6 months ago. He doesnt like all milk product and when he was 3 years old his lergie test was positive for products cow (milk,cheese and meat). He is all the time with running nose and his skin is always with problem. What do you think can he has leaky gut problems?? Thanks,
Hi Eno,
All autoimmune disease has three things in common according to Dr. Fassano – genetic predisposition, environmental trigger and leaky gut.
warmly
Dr Jill
Can reactive arthritis be caused by leaky gut. Can reactive arthritis spread to the lungs and how can this be cured?
Hi Mel,
Yes, leaky gut can contribute to autoimmunity and arthritis.
warmly
Dr Jill
How do thy test for this?
Diagnosis and treatment options for leaky gut covered here
Maybe some of these people who are having trouble getting diagnosed need to be tested for Alpha Gal allergy. It is an anaphylactic tick borne allergy and makes you allergic to all things mammal. Beef, pork, venison, lamb, etc. Many of these people also have trouble with dairy and products made from mammal. It can cause nerve and gut issues, hives, brain fog, itching, shooting pains and many other autoimmune type symptoms. Many of the people in our group were initially diagnosed with so many of these diseases or their doctors just couldn’t figure them out at all. I encourage everyone who can’t get answers to look it up.
Hi Kelly
I appreciate you sharing this, however, I still believe, that even with alpha gal or other hypersensitivity syndromes there is an underlying root cause and immune dysfunction that is causing excessive reactivity.
Warmly
Dr Jill
Hi Jill, 2 years ago I was diagnosed with alopecia I had 1 small balled spot they gave me shots and My hair grew back but now I have self diagnosed my self of having sjogrens dry mouth dry eyes dry nose and a lot of stomach issues . I recently had a colonoscopy and was diagnosed with IBS. Before all of this I knew that I was lactose intolerant but would still eat dairy stupid I know. I’m so discourage I been doing a lot of research and I’ve read plenty of times that sjogrens is like chrons disease basically a gluten sensitivity is this true? can this be caused by leaky gut as well? Also I have a congested liver, do you know what products will help with that? I’ve tried for a few weeks to cut out gluten and dairy haven’t done my best I’m just so scared and I want to heal this. I’m tired of doctors just giving me meds and not looking at the root cause I’m 24 I’m just scared my life is over. what should I test for? I know I have low Vit D levels and that can cause autoimmune disease as well. Please help me thank you kindly! Sorry for all the questions :/
HI Sarinna – it sounds like you need a functional medicine doctor to help you! You may try searching at http://www.functionalmedicine.org by zip code.
warmly
Dr Jill
Hi Dr Jill,
I’m 42 yrs old with Hypothyroid therapy for 8 yrs. I’m taking tbl. Letrox 100 mcg every morning, and blood analysis of thyroid hormones and atpo are in normal ranges BUT my everyday condition is really bad. During the day I feel very tired, I forget e lot, usualy I’m confused, I get bloating of stomach after eating ( no matter what), my Eyebrows are falling ang gone forever…… Could this be linked with leaky gut syndrome ? IS there any gut healing programme for hypothyroid patients like me?
Thank you in advance,
Yes, Doca, if your gut is unhealthy it may affect your thyroid function
Hi Doctor Jill,
I was diagnosed Prurigo nodularis which is skin disease. I got treatments like topical steroids, kenalog injections but no success. At last I realized it is not a cure just a symptom suppression. I did a research on internet and I found that it is actually autoimmune disease which might be caused by leaky gut. I changed my diet/no gluten, no dairy, no processed foods etc/ and taking supplements like MSM, Neem, fish oil also bone broth about 1 month ago. I understand it takes time to cured but I am discouraged and confused, Is my condition really autoimmune disease and am I on a right path?
Hi Zoloo,
Work with a functional medicine doctor in your area to determine root cause of your skin condition and treat that. It is possible that nearly any skin condition can have a root in an dysbiotic gut.
Warmly
Dr Jill
Hi Dr. Jill!
If low iron and ferritin a cause of major hair loss? I’m having major hair loss and have low iron, low ferritin, and high TIBC. My hemoglobin is normal so my doctor keeps saying the hair loss is not related to the iron. I would appreciate your thoughts.
Hi Alexis
Low iron can contribute to hair loss.
warmly
Dr Jill
Hello Dr. Carnahan,
This may be a silly question but if someone has an autoimmune disease which we know is caused by leaky gut and their leaky gut is caused by Candida overgrowth, can they heal their gut by taking l’glutamine? I know that addressing the Candida would be the most important thing but since that can be overwhelming, in the meantime, can l’glutamine heal the gut completely despite the Candida and get rid of the autoimmune disease?
Hi Ashley,
You will not make significant progress healing a leaky gut without addressing the root cause.
warmly
Dr Jill
Hi Dr. Jill,
I developed my first autoimmune disease eczema after taking a very strong antibiotic. I think it was about a month after taking it. I didn’t have eczema before then. I was diagnosed with Hashimoto’s a couple years later. But I’m really starting to worry that I had the Hashi’s first and was just undiagnosed since you can be asymptomatic for a while. I know you can’t tell me which came first but based on your expertise, is it more likely that the eczema came first or could the Hashi’s have been first and the antibiotic created a second autoimmune disease? Thank you!
Hi Ellie
Eczema is an atopic disease but not an autoimmune one.
warmly
Dr Jill
For a year now. I have inner thin eyebrows, it keeps shedding. It falls out, then grows back only 70%.
Can you tell me what might be causing this?
Hi Jack
Loss of eyebrows could be hypothyroid.
Warmly
Dr Jill
Hi Dr. Jill,
What kind of testing should I ask my doctor for to determine the cause of unexplained chronic low ferritin and iron levels?
Thank you,
Jaime
Recommend Cyrex Array 2,3,4 and 10, Comprehensive digestive stool analysis, and urinary organic acid testing
Recently I developed chemical sensitivities and food allergies (non acute) almost to all food including vegetables.
Can not take probiotics, suplements or any type of medication. How to heal gut with this type of gut complication. thank you
You need to test for and treat the underlying cause
What causes severe bloating? My bloating is so bad that I think it might be causing me to have shortness of breath from pushing on my lungs. I have been to doctor after doctor, including functional medicine doctors and gastroenterologists and they don’t know. I’ve been told it could be too much stomach acid, an ovarian cyst, a tumor, etc. Functional medicine doctors I’ve seen wanted to run a CT scan and an endoscopy. The bloating goes down somewhat overnight but I never have a flat stomach, even after sleeping all day and not eating for 16 hours. Please help! I don’t know what to do! I can’t even fit into my blouses anymore!
Hi Tori,
You need to have your doctor check for dysbiosis – yeast, bacterial overgrowth or parasitic infections.
Some toxic exposures can also cause bloating.
warmly
Dr Jill
Also it does get worse after eating (after each meal, doesn’t matter what I eat, even a bowl of fruit) but I would think if it was related to that, I would have a flat stomach after not eating for 16 hours but I don’t. What could this be? Are there certain tests I should ask for?
Hi Dr. Jill, wondering your thoughts on a bacteria called Citrobacter freundii (4+) that grew out on my stool testing. I have problems with fatigue/low energy, GI problems, chronic pain, etc. Also tested positive for H. Pylori. Do you ever use botanical/herbal treatments for H. Pylori or do you recommend antibiotic and PPI treatment? Thank you!
Hi Dr. Jill!
I’ve noticed I’m becoming severely bloated after eating. I can bend over and my belly hangs out several inches past my shorts. Doctors can’t figure it out. I ate 15 grapes earlier and blew up like a balloon but I don’t know if it can be a food sensitivity to grapes because if I eat 2 grapes I’m fine. Do you have any idea what this could be? I couldn’t believe how big my stomach got earlier after eating about 15 grapes.
Hi Sasha,
You likely have dysbiosis, either SIBO or SIFO. Find a functional medicine doctor to order a comprehensive digestive stool analysis and breath test to determine the cause and treat it.
warmly
Dr Jill
Hi Dr. Jill,
I’m anemic and my doctor told me to take a multivitamin with iron because I can’t tolerate iron supplements. I’ve noticed the multivitamin she recommended I take has 18mg of iron but also 15mg of zinc. And if I take 2 a day, that would be 30mg of zinc. I’ve read that taking zinc can actually lower iron levels and a study where they gave women who had low iron 22mg of zinc in addition to an iron supplement, their iron got even lower. What are your thoughts on this?
30mg daily of zinc for most people is safe… you can discuss with your doctor to be sure.
Hi Dr. Jill,
I hate to bother you but I have a question. I’m experiencing severe abdominal bloating, both straight out bloating and also major bloating to the sides (what looks like love handles and one side is slightly bigger than the other). My thighs and butt have now done the same thing too and have ballooned up. They are huge and there is excess fat hanging off of them and I’m very tiny so I shouldn’t have excess fat. So my question is, do you think the bloating my stomach and my thighs and butt are related/caused by the same thing or is it likely to be 2 separate issues? And do you know what this could be? My legs and knees are aching from all this extra weight on them. Thanks in advance! Laura
Hi Laura, you may also have edema
Hi Dr. Jill,
What kinds of things can cause major malabsorption in someone who has Hashimoto’s? I have Hashimoto’s and severe bloating and all around malnutrition. I’m not absorbing what I’m eating, despite eating a lot of fruits and veggies and meats and nutrient rich foods. My face is sunk in, I look sickly pale, my hair is falling out, and I’m experiencing debilitating exhaustion. I can barely scoop food on a plate because my arms are so weak, I look very thin, and you can see bones but I’m not underweight. And my thyroid numbers are not to the point that it would be causing these symptoms. I look very nutritionally deficient and everyone asks me if I’m getting all my nutrients.
Hi Lauren
Infection, toxic exposure, food sensitivities, immune dysfunction or autoimmunity, stress can all cause symptoms
Warmly
Dr Jill
Also I’m having shortness of breath, extreme weakness like in my arms and legs, I don’t even want to move or get off the couch, and my hair is falling out and extremely dry.
Oh and I’m always hungry. I can never get full, no matter how much I eat.
Dr. Jill,
Is Candida overgrowth considered a trigger in the 3 legged stool of autoimmunity? I have Hashimoto’s and I’m trying to get my extremely high antibodies down. I have a bad case of Candida overgrowth. I know Candida causes leaky gut but a lot of things can also cause leaky gut and I was just wondering if I get rid of the Candida (if it’s a trigger), if my antibodies will go down significantly or I could go into remission even if my gut isn’t completely healed? Thank you!
Hi Meghan
Environmental triggers and gut dysbiosis/leaky gut are two of the TRIAD… Environmental triggers can include any infection or toxin. Candida affects intestinal permeability as well. HEre’s a new article on that topic….
warmly
Dr Jill
Hi Dr. Jill,
Have you ever seen TPO antibodies go up by 1,200 in a week and a half in someone who has Hashimoto’s or would you suspect a lab error? Assuming there was no change in diet, stress level, or anything during that time?
They can go up and down. Best to recheck to see if real or lab error
Hi Dr. Jill,
I have Hashimoto’s and I have very painful period cramps. I’m not sure if the 2 are related but I have to take ibuprofen every period because the cramps are so bad, I’m bent over in pain even after taking a small dose of ibuprofen. And I know that ibuprofen isn’t good for leaky gut but without taking it, the pain is unbearable. At times I’ve been standing outside the bathroom about to get sick from the cramps. Is there anything you can think of that would cause bad period cramps like this?
Hi Rachele,
You need to work on your estrogen metabolism… things like DIM, sulhphorophanes and Chaste tree may help
warmly
Dr Jill
Also I have asked my gyn about this and the only thing she suggested is birth control to help with cramps.
Hi Dr. Jill,
I think I may have leaky gut. I was wondering if a B12 level of 498 is considered extremely low and is a sign I’m having malabsorption? Or is my B12 okay or only slightly low?
Karen,
That level is suboptimal
warmly
Dr Jill
Hi,
I have Hashimoto’s and my doctor ran a Genova Comprehensive Stool test to check for infections. I thought it was going to be a 3 day sample but then I realized it is only a 1 day sample. Can a 1 day sample detect every infection? I thought infections like H. Pylori and parasites may not show up in 1 sample. And I want to have accurate results because I’m having very severe bloating and distention in my abdomen.
Hi Savannah
A 3 day sample has higher sensitivity for parasites.
warmly
Dr Jill
Hi Dr. Jill,
I have been experiencing bloating that’s there all the time but gets significantly worse after eating. But I can’t figure out why. If I eat 2 pieces of plain toast with nothing on it, I’m fine. No bloat. Other than the bloat that’s always there but no major increase in bloat. But if I eat spaghetti and meatballs and a salad, major 6 month pregnant looking bloat and major fatigue afterwards. My eyes will feel so heavy, I can barely hold them open. Do you know what could be causing this?
Hi Katherine,
You likely have SIBO (small intestinal bacterial overgrowth) or SIFO (fungal overgrowth) Best to find a functional medicine doctor to do stool testing, organic acid testing and a breath test for SIBO.
Warmly
Dr Jill
Hello,
I was wondering if Vitamin D from the sun still has to be absorbed in the gut/small intestine or if it goes straight to the bloodstream? I have leaky gut and gut infections and a Vitamin D deficiency. I’ve been getting sun every day after supplements didn’t work but then I started wondering if I’m even absorbing it that way or if it still has to be absorbed in the gut. Thank you in advance for your help.
Sun is the very best source of Vitamin D!
Hi Dr. Jill,
What is the fastest and most efficient way you know to get TPO antibodies down? My TPO antibodies are through the roof and I’m majorly panicked. I just want them down quickly but I don’t know what works. 🙁 I’ve researched and found that keeping Vitamin D levels optimal helps and fish oil helps reduce inflammation but I don’t know what actually lowers antibodies fast and is certain to do so? Thank you.
Hi Paige
Going gluten-free is a start… then check for toxic exposure, gut dysbiosis, hidden infections and treat these things, too.
warmly
Dr Jill
Hi Dr. Jill,
I have Raynauds and Hashimoto’s. I’ve read that Raynauds is more common with Lupus and Rheumatoid Arthritis. Does this mean I likely have another autoimmune disease triggering the Raynauds?
Hi Marie,
Having one autoimmune disease does put you at risk for developing another.
warmly
Dr Jill
Hi Dr. Jill!
What is the first thing that should be addressed when someone has had multiple antibiotics, yeast overgrowth, food sensitivities, eczema, nutrient deficiencies, and autoimmune thyroid disease?
Hi Amanda
I recommend starting with elimination diet.
warmly
Dr Jill
Hi Dr. Jill,
I had a GI Effects Stool Profile done and on the first page, it lists EPX and Fecal secretory IgA under Inflammation. I looked under both of those, and they both appear to be in range. They aren’t flagged or anything and looking at the reference range, they look fine. EPX is 1.3 (reference range <=4.6 mcg/g) and Fecal secretory IgA is 313 (reference range <=885 mcg/g). Do you know what would cause these to be flagged under inflammation?
Hi Susie
If they are in the high normal range, Genova will flag the results on the front summary page. I recommend an elimination diet to see if you have food allergies… gluten, dairy, egg, soy, cory, sugar, alcohol, and peanut
Warmly
Dr Jill
Dr. Jill,
I have sarcoidosis. It’s not very popular so I can’t find much information on it. When I read lists like yours with all the other autoimmune diseases it’s not there. But it is another autoimmune condition. Therefore, is it safe to assume that treating the leaky gut will benefit this disease as well? A typical doctor has been treating me with steroids for seven months now. She’s talking now about moving on to chemotherapy. I feel like these treatments are doing more to destroy my body and nothing to really cure the problem. Do you have anything to say about sarcoidosis? If I try what you recommend for other autoimmune conditions would you like to follow up on the results?
Thanks,
Tom
Hi Tom,
Sarcoid can be triggered by toxin, infection, and other things similar to autoimmune disease. It would be worth seeing a functional medicine doctor to see if you can find and reverse a root cause of this illness.
warmly
Dr. Jill
Dr. Jill,
I have an iron deficiency and iron supplements upset my stomach so I can’t take them. Instead my doctor told me to start taking a multivitamin which I did. It has 100% Vitamin C, 100% iron (18 mg), 100% Vitamin E, 100% of all the B vitamins, and 100% Zinc (15 mg). I’ve been taking it for about 2 weeks and I have more energy, the thinning spots on my head where you can see scalp are filling in, the ends of my eyebrows are filling in, there is some pink coming back to my chalky white nails and cheeks, and my lips look less pale. My doctor said it is too soon to retest my iron, but it would be nice to know I’m at least headed in the right direction. But I thought about other nutrients in the multivitamin helping. I’ve read white nails can be caused by malnutrition, not just anemia and you mentioned here in this article that Zinc deficiency can cause hair loss. So I guess I’m just discouraged. It’s helping either way, but I was hoping the multivitamin would get my iron up because my doctor said if not, I might need iron infusions. Does this sound like these are iron related and my iron is going up or that another vitamin in here could be helping?
Thanks,
Brielle
Hi Brielle,
It’s unlikely the vitamin is helping your iron levels but you may be responding to the zinc and other nutrients
warmly
Dr Jill
Hi Dr. Jill,
I was wondering what high benzoic acid and high glutaric acid on an organic acids test mean? Thank you.
Hi Julie
Best to discuss interpretation with your doctor as it may depend on your complete history
warmly
Dr Jill
Hi Dr. Jill,
I’m hoping you can help me. I’ve been to doctor after doctor with no answers. About 10 years ago, I took a strong antibiotic Clindamycin. I was fine for 3 years and then I started getting bloating, yeast infections, eczema, and anxiety. But these were minor issues and overall I was healthy. A couple years later, I was diagnosed with Hashimoto’s and low ferritin. My bloating started getting worse and I was very fatigued and had extreme difficulty keeping on weight but overall I was still functional. Now a couple years later I have extreme fatigue and hair loss but as far as digestive symptoms I have a major 6 month bloat, nausea, upset stomach at times, difficulty keeping on weight, and mushy stool at times. The nausea makes it hard to eat, but sometimes it does go away after eating. And I don’t know quite how to describe this but sometimes my butt feels weird like I’m going to have diarrhea. I’m constipated so that could explain that weird feeling, and I have mushy stool sometimes. And sometimes when I have a bowel movement, I can’t hold it. I have to go right then. I do sleep a lot and I’ve noticed on days when I oversleep, my digestive symptoms like the nausea will get worse. I don’t know if this is simply related to oversleeping or if it could be something else. I have had a stool test done twice through Genova that showed no pathogens, just inflammatory markers. I also had an organic acids test done that seemed to show a very mild yeast problem and possibly a bacterial problem of some sort. Do you think all of this could be related to oversleeping since my digestive symptoms are a lot worse on days when I oversleep or do you think something else is going on? And what would you recommend? Thank you.
Hi Samantha,
It is impossible to make a diagnosis online. I suggest finding a functional medicine doctor near you to help find the root cause of your symptoms. You can search by zip code at http://www.functionalmedicine.org
warmly
Dr Jill
Hi Dr. Jill,
I was wondering if mild Candida (showing up as borderline on an OAT) can be the sole cause of high thyroid antibodies? I have Hashi’s and have high antibodies around 1400. I’ve done a stool test which has showed nothing. I did an OAT through Genova which showed Candida but a very mild case, just borderline. I’m trying to find my root cause and nothing else is showing up. Is it possible that Candida is my root cause even though it’s only borderline?
Hi Angelina
It’s more likely you have increased intestinal permeability which may or may not be related to fungal symbiosis contributing to the autoimmunity…
warmly
Dr Jill
Dr. Jill,
My girlfriend has Raynaud’s and had a Colonoscopy back in the summer for chronic constipation. The Doc could not find anything wrong with her colon and she still has both diseases. Would a Colonoscopy reveal leaky gut / gut permeability problems?
Thanks,
Patrick
Colonoscopy will not reveal any functional disease such as dysbiosis or leaky gut
She has damage to her brainstem area causing both problems. Due to a bad ratio of omega 3 to 6 fats. Needs to get in the sun (especially increase her eye exposure to it), eat lots of oily fish to increase DHA levels (not through supplements!) and check out advice in Jack Kruse’s website for advice on rebuilding brainstem.
Hi Dr. Carnahan,
I’ve heard Zinc is good for healing the gut lining. Is this specifically Zinc Carnosine or any type of Zinc supplement?
Zinc carnosine can be used to heal gastritis but other forms, like zinc chelate or picolinate are also helpful to gut healing
Hi I have a question. When someone has malabsorption of iron related to stuff like leaky gut, yeast overgrowth, can this actually bring their ferritin levels down on its own? Or can ferritin levels only come down from blood loss and malabsorption only prevents the ferritin levels from coming up or making it more difficult for them to come up? Like what I’m asking is I have low ferritin from malabsorption. Did malabsorption actually take it down or did it just not allow it to be absorbed to where my periods took it down each month and it eventually caught up with me? Thanks!
Dear Lydia,
Ferritin may be low due to inflammation or malabsorption without any blood loss… in fact many times that is the case.
warmly
Dr Jill
Hi Dr. Jill,
I hate to bother you, but I have a question. My doctor ordered a ONE urine test through Genova to check for nutritional deficiencies because I don’t look healthy. I look very sick and very malnourished. The test came back completely normal. It is saying I don’t have any nutritional deficiencies and all except for 2 of my vitamins are in green. This doesn’t make any sense to me because a lot of the vitamins shown in green, I have blood test results showing a deficiency like B12, B6, Zinc. And some of those vitamins like Biotin for example I don’t supplement or eat any foods that have it. Plus I have leaky gut and Candida overgrowth so I find it hard to believe all my vitamin levels would be optimal. My doctor’s only explanation is that I’m not nutritionally deficient like we thought and that I’m young so my body is able to compensate. That doesn’t explain how sick I look, how my face is emaciated, and how I look malnourished though. And that doesn’t explain the blood test results showing deficiencies. So I don’t understand…was the test not accurate since it was urine instead of blood?
Hi Sara,
These tests all check different metabolic pathways. It is possible to have nutritional deficiencies in serum that do not show up on ONE profile or to have malabsorption issues that also do not show up. You may want to get Spectracell testing for better intracellular micronutrient analysis.
warmly
Dr. Jill
I have Hashimoto’s and my TPO antibodies have tripled from before when my Vitamin D levels were 30-40. I know this isn’t optimal but now they’re 13. Can this cause antibodies to triple? Does taking Vitamin D lower antibodies?
Vitamin D3 can support the immune system but I don’t know of any reason that taking vitamin D3 would raise antibodies unless the brand you are using contains gluten, soy or other allergen (some do) That’s why I use Thorne Research D3.
Vitamin D levels are 13, not antibodies.
My son is 7 yrs old and he has vitiligo since he was 5. He is allergic from cow product (milk,meat,cheese).
Please what you advice me? Can be a connection between vitiligo and leaky gut?
Thanks,
Almida
Hi Almida
Vitiligo is an autoimmune disorder so I would start by assessing the gut microbiome, intestinal permeability and environmental triggers (toxins, heavy metals, mold, food allergies, etc)
warmly
Dr Jill
Hi,
I had joint problems from November 2014 – June 2015. I would have monthly flare ups that were frustrating and painful. Many doctors were unsure of what I had. My rheumatologist recently told me I have Mixed Connective Tissue Disease and that I HAVE to be on immune suppressants, even though i don’t have symptoms anymore. ANA, Rheumatoid Factor and anti-RNP are all still borderline (as of September).
I cut out Dairy, Gluten, birth control and chemicals and I feel amazing. I haven’t had swelling in over 7 months.
I switched rheumatologists because mine was not very kind and he wouldn’t listen to my opinion much – though I know my body.
I was given 10 different antibiotics in 2014 for UTIs I didn’t even have. They neglected to tell me the labs came back negative.
Do you think those antibiotics messed up my gut and caused this and that’s why cutting out gluten and dairy helped?
If so, how long would it take for my labs to return back to normal?
Thank you for your time,
Helen
*November 2015 – June 2016
Hi Helen,
Yes, antibiotics can trigger dysbiosis and leaky gut
warmly
Dr Jill
Hi,
I was wondering how significantly leaky gut affects nutrient absorption and also, is the absorption worse the leakier your gut is?
Thanks!
Leaky gut and malabsorption commonly co-exsist
Hi i have a lot of unexplained nutrient deficiencies despite taking a multivitamin and exceeding the RDA for these vitamins. I suspect it’s gut related and I want to know what’s going on because my vitamin levels are very low. I was wondering if a CT scan or MRI can show what’s going on in the gut? Can it show Candida and SIBO if they’re present? I saw a picture of Candida in someone’s gut on google so I’m wondering if there’s some type of imaging test that can detect it because all tests functional medicine doctors have ran (stool tests and the like) are coming up negative for everything but I know something is wrong that is causing my nutrient levels to be so low. Also the blood test for Celiac where it tests for gluten antibodies is negative. My doctor has tested me for it twice now. Thanks in advance!
Hi Laura,
A CT or MRI will not show anything in the gut. You need to get comprehensive stool testing and organic acid testing with a functional medicine doctor.
warmly
Dr Jill
How do you reverse villous atrophy caused by SIFO?
Hi Rachel
Treat the SIFO and then heal the gut. The 5-R program works well!
Warmly
Dr Jill
Hi,
My daughter has a leaky gut. For about a year now, her whole body has gotten bigger and she’s really small at 110 pounds. I’m not sure how to describe it other than there is a lot of “excess skin” everywhere on her body that I can grab and she shouldn’t have any excess skin. It’s mainly in her stomach, her sides, her back, and her legs. I have taken her to numerous doctors and specialists. We saw another doctor today and when the doctor said she didn’t see anything wrong and that it’s her shape, I just wanted to burst into tears. People at school are calling my daughter fat and asking if she’s pregnant and why her thighs are so big. She’s swelling so bad that she’s getting stretch marks. And this literally happened overnight. She was small one day and then the next day she ballooned out. She looks like she’s had 10 kids. I don’t know what’s going on, if it’s related to her leaky gut, or something totally different. But the doctors have said they don’t think it’s gut related. So I don’t know. This has been going on for a year now. She sits down and there’s this massive bulge in her stomach and out to the sides and her thighs are huge.
Hi Donna,
This sounds like a cortisol issues. I suggest seeing a functional medicine doctor or endocrinologist to rule out Cushings disorder.
warmly
Dr Jill
Hi Dr. Jill,
I have Hashimoto’s and I’ve had it for a few years. I’m not sure if this is related or not, but about 3 months ago, I started getting constant hunger. I can eat a big meal and still be hungry. I don’t ever get full, no matter how much I eat. Do you know what could be causing this?
it could be hyper or hypothyroid symptoms…. check your medication and labs
Hi,
I have had an iron deficiency and a B12 deficiency for years. It started with just the iron being extremely low, but my B12 was ok. Now they’re both very low with the iron being the worst. My doctor ran tests to check my gut health and found elevated yeast/fungal dysbiosis markers on an OAT. I also have a leaky gut. Does this mean the leaky gut and yeast/fungal dysbiosis is responsible for my low iron and B12 levels? Or could something else be going on? She prescribed Fluconazole. Will that help my body absorb nutrients better? Thank you!
Hi Rachel,
Yes they are likely connected…. if you fix the intestinal dysbiosis then malabsorption syndromes may be reversed.
warmly
Dr. Jill
Hi,
Ever since I was younger (I’m in my 20’s now) right before I get ready to start my period (a few days to a week before) my behavior changes drastically. I get really really mean and nasty to everyone. It happens every month. And I’ve lost friendships as a result. Is there anything that could be causing this?
Yes, imbalance in hormones like estrogen or testosterone may cause you to have mood swings.
Hi Dr. Jill,
When my daughter was younger, she got skin infections that were out of control. She was given strong antibiotics for them which mess up the gut, but I’m really starting to wonder if she had a problem before she took the antibiotics. She got a staph infection on her stomach from wearing a belt too tight that was spreading at the rate of like flesh eating bacteria, only it wasn’t that. It looked like a colony of bacteria growing out to the side and by time she got on antibiotics, it had spread so much it was almost to her back. It was at the edge of her sides about to go to her back. Then 3 years later, she had eczema on her forehead that spread so fast, it was traveling down her face at lightning speed even while she was on antibiotics for it. The bacteria was trying to enter her eyes it was so bad. It was at the edge of her eyes and she would wipe it away with a tissue and it would reappear. Now today she hasn’t had another episode with a rampant infection like that, but she does have eczema, Hashimoto’s, and gut issues like severe bloating and nutrient malabsorption. And I’m wondering did she have a problem before she even took antibiotics, and the antibiotics was the final straw? What can cause infections to just run rampant like that? I would greatly appreciate your thoughts. Thank you!
Hi Marie,
There may be an issue with your daughter’s immunes system. I would have her see an immunologist if you are concerned.
warmly
Dr Jill
Hi Dr. Jill,
What testing would you recommend for severe bloating that is always there 24/7 even if you haven’t eaten in 10-12 hours but does get progressively worse thoroughout the day?
Hi Hannah – I suggest a lactulose breath test to rule out SIBO
Warmly
Dr Jill
Hi Dr. Jill,
I have a bloat that gets worse overnight. The bloat is always there 24/7, but it gets worse overnight. Last night I waited 4 hours after eating before I went to bed. I was bloated but not severely bloated. I woke up severely bloated this morning. Significantly more bloated than when I went to bed. Do you know what this could be?
Hi Jenny
Ask your doctor to check a comprehensive stool test to rule out symbiosis, candida, parasite infections and pancreatic insufficiency
warmly
Dr Jill
Hi,
What can cause significant bloating, low iron and B12 levels, and floating stinky stool?
steatorrhea
Hi Dr. Jill,
About a year ago I started having bloating in my stomach. It kept getting bigger but no other symptoms yet. Then a couple months later, my legs went from stick thin to swelling really bad while my stomach kept getting bigger. It’s now been a year and I’m swollen from head to toe. I’m 130 pounds which is a healthy weight for me. I look like I’m 180 pounds. I have severe swelling all over my body: in my thighs, lower legs, stomach, feet, arms, back, chest/boob area. My boobs are so swollen they are hanging out of the sides of my bra. My stomach and thighs are the worst but my arms are getting really bad too. I have no digestive symptoms. Just the bloating/swelling in my stomach which is the same swelling I get everywhere else. I’m 24 if that helps. My CMP is always normal so my dr acts like that rules out kidney or liver problems. The swelling all over my body gets worse thoroughout the day, SIGNIFICANTLY worse around my period (although it’s there 24/7), and has grown over a year and continues to grow. I used to be stick thin at 130 before. Then I lost a bunch of weight unintentionally and as I gained it all back, I became swollen from head to toe. My dr keeps saying we will watch it because she’s at a loss. The swelling is scaring me! Do you know what this could be? Are there any tests I should ask my dr for?
Hi Emilie
Please find an endocrinologist to see if you have abnormal levels of cortisol
warmly
Dr Jill
Hi Dr. Jill,
Can giving my daughter over the counter liquid children’s Advil 2-3 days out of the month for period cramps (5 times a month max) cause a bad case of leaky gut?
Hi Linda
Best to avoid ibuprofen products if there is an unhealthy gut
Hi Dr. Jill,
Is it true that broccoli and cabbage can help heal a leaky gut? Are they ok to have if you have Hashimoto’s?
Yes, this can be healthy. But too many raw goiterogens can be a problem with Hashimoto’s..
Dr Jill:
A new zero carb way of eating is gaining popularity recently. Those who have gone zero carb by eating only animal products, substantially meat, are reporting some significant health improvements, particularly in the area of autoimmune issues. Personally, I started the eating plan three weeks ago and have experienced a total elimination of two rare skin disorders that have plagued me for years. Not sure what one of them is called but the other is Grover’s Disease. My exema and severe itching has compltely stopped! I have head of others who have had improvements in asthma, arthritis, ect in mere weeks of starting the diet. The all animal product diet eliminates all the lectin and gluten containing foods. I wanted to also point out that anyone trying the diet or actually anyone who regularly consumes meat should make sure their stomach acid levels are sufficient to properly convert pepsinogen to pepsin to thoroughly digest protein and process vit b-12. Many people over 50 have insufficient stomach acid..I being one of them. I am 76 and must supplement each meal with 3-4 Betaine Hydrachloric Acid with Pepsin capsules. I plan on staying on this diet for an additional 30 days and then gradually add some lectin free veggies back in. Grains and sugar will remain out
Hi Dennis
I am a fan of adding back lots of non-starchy veggies and nuts/seeds. You may need to support digestion as you mentioned.
Warmly
Dr Jill
I enjoyed reading your article. I am currently suffering from Graves disease and just did a micronutrient tests showing I am deficient in a handful of nutrients. My functional DR suggest doing the GAPS diet to try and heal my gut. Do you have any suggestions for Graves disease?
Thank you
GAPS is a great way to heal the gut! Graves is complex and you must find the underlying triggers in order to heal. EMF exposure may be a piece of the puzzle.